Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Phenylethanolamine N-methyltransferase | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0134 | 0.3572 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0119 | 0.3076 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0345 | 0.0345 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0034 | 0.0345 | 0.0966 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0034 | 0.0345 | 0.1122 |
Echinococcus granulosus | voltage gated potassium channel | 0.0034 | 0.0345 | 0.0966 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0034 | 0.0345 | 0.1122 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0034 | 0.0345 | 0.1122 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0034 | 0.0345 | 0.0345 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0134 | 0.3572 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0034 | 0.0345 | 0.1122 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0333 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.21 | Inhibition of [3H]-clonidine binding to the rat alpha2-adrenoceptor | ChEMBL. | 10091706 |
Ki (binding) | = 5.31 | Inhibitory activity against bovine adrenal phenylethanolamine N-methyltransferase (PNMT) | ChEMBL. | 10091706 |
Ki (binding) | = 4.9 uM | In vitro inhibitory activity against bovine adrenal phenylethanolamine N-methyltransferase (PNMT) | ChEMBL. | 9888838 |
Ki (binding) | = 4.9 uM | In vitro inhibitory activity against bovine adrenal phenylethanolamine N-methyltransferase (PNMT) | ChEMBL. | 9888838 |
Ki (binding) | = 5 uM | Inhibition of bovine PNMT by radiochemical assay | ChEMBL. | 18024134 |
Ki (binding) | = 5 uM | Inhibition of bovine PNMT by radiochemical assay | ChEMBL. | 18024134 |
Ki (binding) | = 6.1 uM | In vitro inhibitory activity against Alpha-2 adrenergic receptor using [3H]-clonidine as radioligand in male Sparague-Dawley rats | ChEMBL. | 9888838 |
Ki (binding) | = 6.1 uM | In vitro inhibitory activity against Alpha-2 adrenergic receptor using [3H]-clonidine as radioligand in male Sparague-Dawley rats | ChEMBL. | 9888838 |
Log Ki (binding) | = 5.21 | Inhibition of [3H]-clonidine binding to the rat alpha2-adrenoceptor | ChEMBL. | 10091706 |
Log Ki (binding) | = 5.31 | Inhibitory activity against bovine adrenal phenylethanolamine N-methyltransferase (PNMT) | ChEMBL. | 10091706 |
Selectivity (binding) | = 1.2 | Binding selectivity against PNMT and alpha2-adrenoceptors, measured as a ratio of respective in vitro Ki's. | ChEMBL. | 9888838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.