Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0052 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0052 | 0 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0052 | 0 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0055 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase | 0.0055 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.6174 | 0.6174 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0055 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0055 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | CAMKK/META protein kinase | 0.0055 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0055 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0055 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.6174 | 0.6174 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.6174 | 0.6174 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0052 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0052 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.3 ug ml-1 | In vitro minimum inhibitory concentration against Candida tropicalis Berkout KCCM 50662 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | = 25 ug ml-1 | In vitro minimum inhibitory concentration against Candida krusei Berkout KCCM 11655 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | > 50 ug ml-1 | In vitro minimum inhibitory concentration against Candida albicans Berkout KCCM 50235 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | > 50 ug ml-1 | In vitro minimum inhibitory concentration against Aspergillus niger KCTC 1231 strain at 37 degree C after 2 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | > 50 ug ml-1 | In vitro minimum inhibitory concentration against Candida albicans Berkout KCCM 50235 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.