Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Ryanodine receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.545 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0056 | 0.1426 | 0.0878 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Echinococcus granulosus | ryanodine receptor 44f | 0.0149 | 0.765 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0116 | 0.545 | 0.6879 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0116 | 0.545 | 0.6879 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | ryanodine receptor | 0.0069 | 0.2263 | 0.4153 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0066 | 0.2103 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | ryanodine receptor | 0.0043 | 0.0565 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0044 | 0.0601 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0044 | 0.0601 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0066 | 0.2103 | 0.5 |
Brugia malayi | cation channel family protein | 0.0079 | 0.293 | 0.2478 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Schistosoma mansoni | ryanodine receptor related | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0149 | 0.765 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0696 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0044 | 0.0601 | 0.1102 |
Onchocerca volvulus | 0.0044 | 0.0601 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0045 | 0.0677 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0601 | 0.1102 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 43.6 nM | Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesicles | ChEMBL. | 8388466 |
IC50 (binding) | = 43.6 nM | Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesicles | ChEMBL. | 8388466 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.