Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0183 | 0.1242 | 0.4423 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.039 | 0.2775 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0104 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0027 | 0.0076 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0308 | 0.1092 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.039 | 0.2775 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0026 | 0.0026 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0308 | 0.1025 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0347 | 0.2455 | 0.8842 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0026 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0026 | 0.0026 |
Echinococcus granulosus | traf and tnf receptor associated protein | 0.0352 | 0.2493 | 0.2493 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0104 | 0.0284 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.137 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0194 | 0.0608 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 0.1242 | 0.4465 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0308 | 0.1025 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.039 | 0.2775 | 0.2775 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0178 | 0.0621 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0026 | 0.0026 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.039 | 0.2775 | 0.2775 |
Toxoplasma gondii | MAPEG family protein | 0.137 | 1 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.1154 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0026 | 0.0026 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0194 | 0.0194 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0104 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0308 | 0.1092 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.039 | 0.2775 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0194 | 0.0194 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0194 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0026 | 0.0074 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0006 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.1298 | 0.1298 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0026 | 0.0026 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0178 | 0.0551 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0027 | 0.0027 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.039 | 0.2775 | 0.2775 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0026 | 0.0026 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.137 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0026 | 0.0026 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.039 | 0.2775 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0027 | 0.0027 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0194 | 0.0194 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0226 | 0.1563 | 0.1563 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0226 | 0.1563 | 0.1563 |
Echinococcus granulosus | geminin | 0.019 | 0.1298 | 0.1298 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0026 | 0.0074 |
Echinococcus multilocularis | traf and tnf receptor associated protein | 0.0352 | 0.2493 | 0.2493 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0027 | 0.0076 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.039 | 0.2775 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0178 | 0.0178 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0026 | 0.0026 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0006 | 0.0006 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0342 | 0.2418 | 0.2337 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.039 | 0.2775 | 1 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.1298 | 0.1298 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.137 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.019 | 0.1298 | 0.1298 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0104 | 0.5 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0031 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0104 | 0.0356 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.039 | 0.2775 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0026 | 0.0026 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0352 | 0.2493 | 0.8975 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 190 nM | Inhibition of human vascular endothelial growth factor receptor 2 kinase activity | ChEMBL. | 15943473 |
IC50 (binding) | = 190 nM | Inhibition of human vascular endothelial growth factor receptor 2 kinase activity | ChEMBL. | 15943473 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.