Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily A, polypeptide 6 | Starlite/ChEMBL | References |
Mus musculus | cytochrome P450, family 2, subfamily a, polypeptide 5 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 1, subfamily A, polypeptide 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily A, polypeptide 6 | 494 aa | 485 aa | 32.8 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily a, polypeptide 5 | 494 aa | 484 aa | 32.6 % |
Brugia malayi | Cytochrome P450 family protein | cytochrome P450, family 1, subfamily A, polypeptide 2 | 516 aa | 470 aa | 26.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0036 | 0.0347 | 0.4125 |
Toxoplasma gondii | ribonuclease HI protein | 0.0047 | 0.0841 | 1 |
Leishmania major | ribonuclease H1, putative | 0.0047 | 0.0841 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0137 | 0.4839 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0036 | 0.0347 | 0.4125 |
Echinococcus granulosus | GPCR family 2 | 0.0054 | 0.1155 | 0.1798 |
Giardia lamblia | Ribonuclease H | 0.0047 | 0.0841 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0117 | 0.394 | 0.394 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0253 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0171 | 0.6341 | 0.6341 |
Brugia malayi | RNase H family protein | 0.0047 | 0.0841 | 0.0841 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0036 | 0.0347 | 0.0527 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0054 | 0.1155 | 0.1155 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.1155 | 0.1798 |
Brugia malayi | Isocitrate dehydrogenase | 0.0036 | 0.0347 | 0.0347 |
Trypanosoma brucei | ribonuclease H1 | 0.0047 | 0.0841 | 0.1278 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0036 | 0.0347 | 0.4125 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0051 | 0.1018 | 0.1548 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4839 | 0.7208 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1155 | 0.1155 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0036 | 0.0347 | 1 |
Brugia malayi | RNase H family protein | 0.0047 | 0.0841 | 0.0841 |
Loa Loa (eye worm) | RNA binding protein | 0.0137 | 0.4839 | 0.4839 |
Brugia malayi | RNase H family protein | 0.0047 | 0.0841 | 0.0841 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4839 | 0.7208 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0051 | 0.1018 | 0.1548 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0047 | 0.0841 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0036 | 0.0347 | 0.0527 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0047 | 0.0841 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1155 | 0.1296 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.6579 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.394 | 0.5766 |
Brugia malayi | TAR-binding protein | 0.0137 | 0.4839 | 0.4839 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0137 | 0.4839 | 0.4839 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4839 | 0.7208 |
Echinococcus granulosus | ribonuclease H1 | 0.0047 | 0.0841 | 0.11 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0036 | 0.0347 | 0.4125 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0051 | 0.1018 | 0.1548 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0171 | 0.6341 | 0.6341 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0036 | 0.0347 | 0.0347 |
Brugia malayi | isocitrate dehydrogenase | 0.0036 | 0.0347 | 0.0347 |
Brugia malayi | RNA binding protein | 0.0137 | 0.4839 | 0.4839 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0054 | 0.1155 | 0.1155 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0047 | 0.0841 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.394 | 0.394 |
Loa Loa (eye worm) | TAR-binding protein | 0.0137 | 0.4839 | 0.4839 |
Schistosoma mansoni | phosphoglucomutase | 0.0047 | 0.0841 | 0.0793 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.1155 | 0.1798 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4839 | 0.7208 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0137 | 0.4839 | 0.4839 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.1155 | 0.1798 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0036 | 0.0347 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0036 | 0.0347 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0054 | 0.1155 | 0.1798 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.6341 | 0.6341 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0047 | 0.0841 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0051 | 0.1018 | 0.1548 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1155 | 0.1296 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0047 | 0.0841 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0051 | 0.1018 | 0.1548 |
Schistosoma mansoni | phosphoglucomutase | 0.0047 | 0.0841 | 0.0793 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0171 | 0.6341 | 0.6341 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.1155 | 0.1798 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1155 | 0.1296 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0253 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4839 | 0.7208 |
Trypanosoma brucei | RNA helicase, putative | 0.0176 | 0.6579 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0054 | 0.1155 | 0.1155 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1155 | 0.1296 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0036 | 0.0347 | 0.4125 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0047 | 0.0841 | 0.5 |
Echinococcus multilocularis | ribonuclease H1 | 0.0047 | 0.0841 | 0.11 |
Echinococcus multilocularis | tar DNA binding protein | 0.0137 | 0.4839 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0047 | 0.0841 | 0.0793 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 5.602 | Inhibition of human CYP2A6 | ChEMBL. | 19110342 |
IC50 (ADMET) | = 5.62 | Inhibition of mouse CYP2A5 | ChEMBL. | 19110342 |
IC50 (ADMET) | = 2.4 uM | Inhibitory concentration against mouse cytochrome P450 2A5 | ChEMBL. | 15658857 |
IC50 (ADMET) | = 2.4 uM | Inhibitory concentration against mouse cytochrome P450 2A5 | ChEMBL. | 15658857 |
IC50 (ADMET) | = 2.5 uM | Inhibitory concentration against human cytochrome P450 2A6 | ChEMBL. | 15658857 |
IC50 (ADMET) | = 2.5 uM | Inhibitory concentration against human cytochrome P450 2A6 | ChEMBL. | 15658857 |
IC50 (ADMET) | = 14 uM | Inhibitory concentration against recombinant human cytochrome P450 1A2 | ChEMBL. | 15916432 |
IC50 (ADMET) | = 14 uM | Inhibitory concentration against recombinant human cytochrome P450 1A2 | ChEMBL. | 15916432 |
Ratio (ADMET) | = 1.04 | Ratio of IC50 for human CYP2A6 to that of mouse CYP2A5 was determined | ChEMBL. | 15658857 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.