Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | CAMKK/META protein kinase | 0.0059 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0059 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0059 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0059 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0059 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0059 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0057 | 0 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0057 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0057 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0057 | 0 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.6174 | 0.6174 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0059 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.6174 | 0.6174 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0059 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0057 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0059 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0057 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.6174 | 0.6174 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0057 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | nM | Inhibitory activity against constitutively activated human Neuropeptide Y receptor Y5 stransiently expressed in COS-1 cells using [125I]-PYY; NE - Not evaluated | ChEMBL. | 15863317 |
IC50 (binding) | nM | Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]-MK912; NE - Not evaluated | ChEMBL. | 15863317 |
IC50 (binding) | 0 nM | Inhibitory activity against constitutively activated human Neuropeptide Y receptor Y5 stransiently expressed in COS-1 cells using [125I]-PYY; NE - Not evaluated | ChEMBL. | 15863317 |
IC50 (binding) | 0 nM | Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]-MK912; NE - Not evaluated | ChEMBL. | 15863317 |
IC50 (binding) | > 10000 nM | Inhibitory activity against mutated constitutively activated human Melanin concentrating hormone receptor 1 (CA-MCH-R1) stably expressed in HEK293 cells using [125I](Phe13, Tyr19) MCH | ChEMBL. | 15863317 |
IC50 (binding) | > 10000 nM | Inhibitory activity against mutated constitutively activated human Melanin concentrating hormone receptor 1 (CA-MCH-R1) stably expressed in HEK293 cells using [125I](Phe13, Tyr19) MCH | ChEMBL. | 15863317 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.