Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Phenylalanyl-tRNA synthetase alpha chain | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 314 aa | 27.1 % |
Echinococcus granulosus | phenylalanyl tRNA synthetase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 291 aa | 29.6 % |
Theileria parva | phenylalanyl-tRNA synthetase, putative | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 315 aa | 24.4 % |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 315 aa | 28.3 % |
Candida albicans | phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 314 aa | 27.1 % |
Onchocerca volvulus | Presenilins-associated rhomboid-like protein, mitochondrial homolog | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 396 aa | 25.0 % |
Babesia bovis | phenylalanine-tRNA ligase, putative | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 359 aa | 24.8 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 58 nM | Inhibitory concentration against Staphylococcus aureus Phenylalanyl-tRNA synthetase | ChEMBL. | 15837314 |
IC50 (binding) | = 58 nM | Inhibitory concentration against Staphylococcus aureus Phenylalanyl-tRNA synthetase | ChEMBL. | 15837314 |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 2.61 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.78 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.47 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 10 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 98 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 99 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 1.56 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -1 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 10 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 98 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 99 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.07 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.8448 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.