Detailed information for compound 340497

Basic information

Technical information
  • TDR Targets ID: 340497
  • Name: 2-[2-[[[2-(4-bromothiophen-2-yl)-2-hydroxyeth yl]amino]methyl]phenoxy]-N-[2-(methylamino)-2 -oxoethyl]acetamide
  • MW: 456.354 | Formula: C18H22BrN3O4S
  • H donors: 4 H acceptors: 3 LogP: 1.2 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)CNC(=O)COc1ccccc1CNCC(c1scc(c1)Br)O
  • InChi: 1S/C18H22BrN3O4S/c1-20-17(24)9-22-18(25)10-26-15-5-3-2-4-12(15)7-21-8-14(23)16-6-13(19)11-27-16/h2-6,11,14,21,23H,7-10H2,1H3,(H,20,24)(H,22,25)
  • InChiKey: VZSNYQDFEGWGQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-[[[2-(4-bromo-2-thienyl)-2-hydroxy-ethyl]amino]methyl]phenoxy]-N-[2-(methylamino)-2-oxo-ethyl]acetamide
  • 2-[2-[[[2-(4-bromo-2-thienyl)-2-hydroxyethyl]amino]methyl]phenoxy]-N-[2-(methylamino)-2-oxoethyl]acetamide
  • 2-[2-[[[2-(4-bromothiophen-2-yl)-2-hydroxy-ethyl]amino]methyl]phenoxy]-N-[2-(methylamino)-2-oxo-ethyl]ethanamide
  • 2-[2-[[[2-(4-bromo-2-thienyl)-2-hydroxy-ethyl]amino]methyl]phenoxy]-N-[2-keto-2-(methylamino)ethyl]acetamide
  • 2-[2-[[[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]amino]methyl]phenoxy]-N-(2-methylamino-2-oxoethyl)acetamide
  • 2-[2-[[[2-(4-bromo-2-thienyl)-2-hydroxy-ethyl]amino]methyl]phenoxy]-N-(2-methylamino-2-oxo-ethyl)acetamide
  • 2-[2-[[[2-(4-bromo-2-thienyl)-2-hydroxyethyl]amino]methyl]phenoxy]-N-(2-methylamino-2-oxoethyl)acetamide
  • 2-[2-[[[2-(4-bromo-2-thienyl)-2-hydroxy-ethyl]amino]methyl]phenoxy]-N-(2-keto-2-methylamino-ethyl)acetamide
  • 2-[2-[[[2-(4-bromothiophen-2-yl)-2-hydroxy-ethyl]amino]methyl]phenoxy]-N-(2-methylamino-2-oxo-ethyl)ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Staphylococcus aureus Phenylalanyl-tRNA synthetase alpha chain Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Cryptosporidium parvum putative phenylalanyl-tRNA synthetase Get druggable targets OG5_127036 All targets in OG5_127036
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania donovani phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B Get druggable targets OG5_127036 All targets in OG5_127036
Chlamydia trachomatis phenylalanine--tRNA ligase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma congolense phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS Get druggable targets OG5_127036 All targets in OG5_127036
Schistosoma japonicum ko:K01889 phenylalanyl-tRNA synthetase alpha chain [EC6.1.1.20A], putative Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma brucei gambiense phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium berghei phenylalanine--tRNA ligase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Brugia malayi phenylalanyl (f) trna synthetase protein 1 Get druggable targets OG5_127036 All targets in OG5_127036
Theileria parva phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania mexicana phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit Get druggable targets OG5_127036 All targets in OG5_127036
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania braziliensis phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Candida albicans phenylalanyl-tRNA synthetase Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania infantum phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B Get druggable targets OG5_127036 All targets in OG5_127036
Neospora caninum hypothetical protein Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium yoelii phenylalanyl-tRNA synthetase, putative Get druggable targets OG5_127036 All targets in OG5_127036
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS Get druggable targets OG5_127036 All targets in OG5_127036
Babesia bovis phenylalanyl-tRNA synthetase family protein Get druggable targets OG5_127036 All targets in OG5_127036
Cryptosporidium hominis phenylalanyl-trna synthetase-like protein Get druggable targets OG5_127036 All targets in OG5_127036
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Candida albicans phenylalanyl-tRNA synthetase Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium knowlesi phenylalanine--tRNA ligase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Presenilins-associated rhomboid-like protein, mitochondrial homolog Phenylalanyl-tRNA synthetase alpha chain   352 aa 396 aa 25.0 %
Babesia bovis phenylalanine-tRNA ligase, putative Phenylalanyl-tRNA synthetase alpha chain   352 aa 359 aa 24.8 %
Echinococcus multilocularis phenylalanyl tRNA synthetase Phenylalanyl-tRNA synthetase alpha chain   352 aa 315 aa 28.3 %
Candida albicans phenylalanine--tRNA ligase Phenylalanyl-tRNA synthetase alpha chain   352 aa 314 aa 27.1 %
Theileria parva phenylalanyl-tRNA synthetase, putative Phenylalanyl-tRNA synthetase alpha chain   352 aa 315 aa 24.4 %
Echinococcus granulosus phenylalanyl tRNA synthetase Phenylalanyl-tRNA synthetase alpha chain   352 aa 291 aa 29.6 %
Candida albicans phenylalanine--tRNA ligase Phenylalanyl-tRNA synthetase alpha chain   352 aa 314 aa 27.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0625 0.7893 1
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0114 0.0144
Schistosoma mansoni biogenic amine receptor 0.0047 0.0114 0.0114
Brugia malayi Serotonin receptor 0.0047 0.0114 0.0144
Onchocerca volvulus 0.0047 0.0114 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni neuropeptide receptor 0.0047 0.0114 0.0114
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0237 0.0301
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Brugia malayi hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni opsin-like receptor 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni adenoreceptor 0.0047 0.0114 0.0114
Brugia malayi larval opioid receptor 0.0047 0.0114 0.0144
Schistosoma mansoni biogenic amine receptor 0.0047 0.0114 0.0114
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.0114 0.0114
Onchocerca volvulus 0.0047 0.0114 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni amine GPCR 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0782 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni hypothetical protein 0.0047 0.0114 0.0114
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0114 0.0114
Onchocerca volvulus 0.0047 0.0114 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Onchocerca volvulus 0.0047 0.0114 0.5
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0088 0.0676 0.5
Schistosoma mansoni opsin-like receptor 0.0047 0.0114 0.0114
Brugia malayi neuropeptide F receptor 0.0047 0.0114 0.0144
Onchocerca volvulus 0.0047 0.0114 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0114 0.0114
Onchocerca volvulus 0.0047 0.0114 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0625 0.7893 0.7893
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni hypothetical protein 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni amine GPCR 0.0047 0.0114 0.0114
Brugia malayi hypothetical protein 0.0047 0.0114 0.0144
Brugia malayi GnHR receptor homolog 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Brugia malayi hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0047 0.0114 0.0114
Schistosoma mansoni biogenic amine (5HT) receptor 0.0527 0.6571 0.6571
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni biogenic amine receptor 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.0114 0.0144
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0114 0.0114
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Onchocerca volvulus 0.0047 0.0114 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0237 0.0301
Brugia malayi hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0114 0.0114
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0237 0.0301
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.0114 0.0144
Brugia malayi sulfakinin receptor protein 0.0047 0.0114 0.0144
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0676 0.5
Echinococcus multilocularis serotonin receptor 0.0527 0.6571 0.6532
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.0114 0.0144
Schistosoma mansoni neuropeptide receptor 0.0047 0.0114 0.0114
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.0114 0.0114
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0114 0.0144
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.0114 0.0144
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0114 0.0114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0114 0.0114
Brugia malayi AKH receptor 0.0047 0.0114 0.0144
Schistosoma mansoni hypothetical protein 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Brugia malayi putative neuropeptide receptor 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.0114 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0782 1 1
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0676 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0088 0.0676 0.0857
Brugia malayi Melatonin receptor type 1A 0.0047 0.0114 0.0144
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.0114 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0237 0.0301
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0088 0.0676 0.5
Brugia malayi hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Onchocerca volvulus 0.0047 0.0114 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0114 0.0114
Onchocerca volvulus 0.0047 0.0114 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.0114 0.0114
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0088 0.0676 0.0676
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.0114 0.0144
Brugia malayi hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni lipoxygenase 0.0104 0.0883 0.0883
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.0114 0.0114
Schistosoma mansoni opsin-like receptor 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0088 0.0676 0.0569
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0114 0.0114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0114 0.0114
Schistosoma mansoni histamine h1 receptor 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0088 0.0676 0.0569
Schistosoma mansoni amine GPCR 0.0047 0.0114 0.0114
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0088 0.0676 0.5
Onchocerca volvulus 0.0047 0.0114 0.5
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0676 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0114 0.0114
Echinococcus granulosus biogenic amine 5HT receptor 0.0527 0.6571 0.6532
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0104 0.0883 0.0778
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0088 0.0676 0.5
Brugia malayi Serotonin receptor 0.0047 0.0114 0.0144
Chlamydia trachomatis phenylalanine--tRNA ligase subunit alpha 0.0422 0.5159 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.0114 0.0114
Brugia malayi hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0527 0.6571 0.8325
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0114 0.0144
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0114 0.0144
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0422 0.5159 0.5
Brugia malayi G-protein coupled receptor 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0625 0.7893 1
Brugia malayi hypothetical protein 0.0047 0.0114 0.0144
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0104 0.0883 0.0778
Schistosoma mansoni neuropeptide receptor 0.0047 0.0114 0.0114
Schistosoma mansoni amine GPCR 0.0047 0.0114 0.0114
Schistosoma mansoni myosin xvIII 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.0114 0.0144
Brugia malayi Dopamine receptor protein 1 0.0047 0.0114 0.0144
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0625 0.7893 1
Brugia malayi G-protein coupled receptor 0.0047 0.0114 0.0144
Brugia malayi RE15519p 0.0047 0.0114 0.0144
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.0114 0.0144
Brugia malayi neuropeptide F receptor 0.0047 0.0114 0.0144
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.0422 0.5159 0.5
Echinococcus multilocularis serotonin receptor 0.0527 0.6571 0.6532
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0088 0.0676 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.0114 0.0114
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Brugia malayi ORL1-like opioid receptor 0.0047 0.0114 0.0144
Onchocerca volvulus 0.0047 0.0114 0.5
Schistosoma mansoni lipoxygenase 0.0073 0.0463 0.0463
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.0114 0.0114
Schistosoma mansoni amine GPCR 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Brugia malayi hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.0114 0.0114
Onchocerca volvulus 0.0047 0.0114 0.5
Brugia malayi hypothetical protein 0.0047 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Brugia malayi follicle stimulating hormone receptor 0.0047 0.0114 0.0144
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0527 0.6571 0.8325
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.0114 0.0144
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.0114 0.0144
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.0114 0.0144
Brugia malayi Dopamine receptor 0.0047 0.0114 0.0144
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.0422 0.5159 0.5
Onchocerca volvulus 0.0047 0.0114 0.5
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0088 0.0676 0.0857
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.0114 0.0114
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.0114 0.0144
Onchocerca volvulus 0.0047 0.0114 0.5
Onchocerca volvulus 0.0047 0.0114 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0114 0.0114
Schistosoma mansoni neuropeptide receptor 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0114 0.0114
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0088 0.0676 0.5
Onchocerca volvulus 0.0047 0.0114 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0676 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0114 0.0114
Brugia malayi G protein-coupled receptor 0.0047 0.0114 0.0144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0063 0.0332 0.5
Onchocerca volvulus 0.0047 0.0114 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0144
Brugia malayi Dopamine receptor protein 2 0.0047 0.0114 0.0144

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 120 nM Inhibitory concentration against Staphylococcus aureus Phenylalanyl-tRNA synthetase ChEMBL. 15837314
IC50 (binding) = 120 nM Inhibitory concentration against Staphylococcus aureus Phenylalanyl-tRNA synthetase ChEMBL. 15837314

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.