Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | ingi protein (ORF1) | 0.0691 | 0.2747 | 0.2728 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.0026 | 0.0025 |
Toxoplasma gondii | ribonuclease HI protein | 0.0637 | 0.2515 | 0.5 |
Giardia lamblia | Ribonuclease H | 0.0637 | 0.2515 | 1 |
Echinococcus multilocularis | ribonuclease H1 | 0.0637 | 0.2515 | 1 |
Trichomonas vaginalis | NeSL-1_NeSL reverse transcriptases, putative | 0.0054 | 0.0025 | 0.0099 |
Trichomonas vaginalis | reverse transcriptases, putative | 0.0054 | 0.0025 | 0.0099 |
Trypanosoma brucei | RNA helicase, putative | 0.2388 | 1 | 1 |
Trichomonas vaginalis | reverse transcriptases, putative | 0.0054 | 0.0025 | 0.0099 |
Trypanosoma brucei | unspecified product | 0.0691 | 0.2747 | 0.2728 |
Trichomonas vaginalis | reverse transcriptase [C. elegans], putative | 0.0054 | 0.0025 | 0.0099 |
Schistosoma mansoni | phosphoglucomutase | 0.0637 | 0.2515 | 0.2514 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0025 | 0.0024 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0095 | 0.0199 | 0.0697 |
Brugia malayi | RNase H family protein | 0.0637 | 0.2515 | 1 |
Brugia malayi | RNase H family protein | 0.0637 | 0.2515 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0637 | 0.2515 | 0.2514 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0691 | 0.2747 | 0.2728 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0691 | 0.2747 | 0.2728 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0691 | 0.2747 | 0.2728 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0637 | 0.2515 | 1 |
Echinococcus granulosus | ribonuclease H1 | 0.0637 | 0.2515 | 1 |
Leishmania major | ribonuclease H1, putative | 0.0637 | 0.2515 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0637 | 0.2515 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0095 | 0.0199 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0637 | 0.2515 | 1 |
Schistosoma mansoni | scy1(yeast) protein kinase-like | 0.0054 | 0.0025 | 0.0024 |
Loa Loa (eye worm) | IRE protein kinase | 0.0095 | 0.0199 | 0.5 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0637 | 0.2515 | 1 |
Trypanosoma brucei | ribonuclease H1 | 0.0637 | 0.2515 | 0.2497 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0095 | 0.0199 | 0.0697 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0025 | 0.0024 |
Schistosoma mansoni | phosphoglucomutase | 0.0637 | 0.2515 | 0.2514 |
Schistosoma mansoni | protein kinase | 0.0054 | 0.0025 | 0.0024 |
Brugia malayi | RNase H family protein | 0.0637 | 0.2515 | 1 |
Mycobacterium tuberculosis | Possible maturase | 0.0054 | 0.0025 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0095 | 0.0199 | 0.0697 |
Entamoeba histolytica | protein kinase, putative | 0.0095 | 0.0199 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0637 | 0.2515 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0637 | 0.2515 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0 nM | Effective concentration required for induction of tyrosine aminotransferase in human HepG2 cells using 13% radiolabeled dexamethasone; ND.=not determined | ChEMBL. | 15911283 |
EC50 (functional) | 0 nM | Effective concentration required for induction of glutamine synthetase in human skeletal muscle cells using 5% radiolabeled dexamethasone; ND.=not determined | ChEMBL. | 15911283 |
EC50 (functional) | 0 nM | Effective concentration required for inhibition of interleukin-6 in human A549 lung carcinoma cell line using 21% radiolabeled dexamethasone; ND.=not determined because single point inhibition at 3 uM was observed | ChEMBL. | 15911283 |
EC50 (functional) | = 91 nM | Effective concentration required for inhibition of interleukin-6 in mouse thioglycolate-elicited peritoneal exudate cell line using 70% radiolabeled dexamethasone | ChEMBL. | 15911283 |
EC50 (functional) | = 91 nM | Effective concentration required for inhibition of interleukin-6 in mouse thioglycolate-elicited peritoneal exudate cell line using 70% radiolabeled dexamethasone | ChEMBL. | 15911283 |
IC50 (binding) | = 8.5 nM | Inhibition of human glucocorticoid receptor alpha isoform | ChEMBL. | 15911283 |
IC50 (binding) | = 8.5 nM | Inhibition of human glucocorticoid receptor alpha isoform | ChEMBL. | 15911283 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 15911283 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.