Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Phenylalanyl-tRNA synthetase alpha chain | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 314 aa | 27.1 % |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 315 aa | 28.3 % |
Theileria parva | phenylalanyl-tRNA synthetase, putative | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 315 aa | 24.4 % |
Babesia bovis | phenylalanine-tRNA ligase, putative | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 359 aa | 24.8 % |
Onchocerca volvulus | Presenilins-associated rhomboid-like protein, mitochondrial homolog | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 396 aa | 25.0 % |
Echinococcus granulosus | phenylalanyl tRNA synthetase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 291 aa | 29.6 % |
Candida albicans | phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase alpha chain | 352 aa | 314 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.1067 | 0.5 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0088 | 0.1067 | 0.5 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.1067 | 0.5 |
Onchocerca volvulus | Deterin homolog | 0.0053 | 0.0107 | 0.5 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0088 | 0.1067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.1067 | 1 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0088 | 0.1067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0107 | 0.1001 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0088 | 0.1067 | 0.5 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0088 | 0.1067 | 1 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.0422 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0107 | 0.1001 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0088 | 0.1067 | 0.5 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0088 | 0.1067 | 0.5 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0088 | 0.1067 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0053 | 0.0107 | 0.1001 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0088 | 0.1067 | 1 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0063 | 0.0381 | 0.5 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.1067 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0053 | 0.0107 | 0.1001 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.0422 | 1 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.0107 | 0.5 | |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0088 | 0.1067 | 1 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0422 | 1 | 0.5 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0.1067 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 190 nM | Inhibitory concentration against Staphylococcus aureus Phenylalanyl-tRNA synthetase | ChEMBL. | 15837314 |
IC50 (binding) | = 190 nM | Inhibitory concentration against Staphylococcus aureus Phenylalanyl-tRNA synthetase | ChEMBL. | 15837314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.