Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0084 | 0.1698 | 0.1698 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0089 | 0.195 | 0.5 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0084 | 0.1698 | 0.1698 |
Echinococcus granulosus | serotonin transporter | 0.0089 | 0.195 | 0.0303 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0084 | 0.1698 | 0.1698 |
Loa Loa (eye worm) | serotonin transporter b | 0.0089 | 0.195 | 1 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | serotonin receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | g protein coupled receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | neuropeptide receptor | 0.0084 | 0.1698 | 0.1698 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0089 | 0.195 | 1 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0084 | 0.1698 | 0.1698 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0089 | 0.195 | 0.0395 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0084 | 0.1698 | 0.1698 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.195 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | somatostatin receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | sex peptide receptor | 0.0084 | 0.1698 | 0.1698 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.195 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0084 | 0.1698 | 0.1698 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0089 | 0.195 | 1 |
Echinococcus multilocularis | allatostatin A receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | g protein coupled receptor | 0.0084 | 0.1698 | 0.1698 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.195 | 1 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | fmrfamide receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | fmrfamide receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0167 | 0.6645 | 0.6645 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0084 | 0.1698 | 0.1698 |
Onchocerca volvulus | 0.0089 | 0.195 | 1 | |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0084 | 0.1698 | 0.1698 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0191 | 0.8069 | 1 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0223 | 1 | 1 |
Echinococcus multilocularis | neuropeptide receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | g protein coupled receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0084 | 0.1698 | 0.1698 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0089 | 0.195 | 0.0395 |
Echinococcus multilocularis | serotonin receptor | 0.0084 | 0.1698 | 0.1698 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0089 | 0.195 | 1 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0084 | 0.1698 | 0.1698 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0084 | 0.1698 | 0.1698 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0167 | 0.6645 | 0.5958 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0175 | 0.7127 | 0.654 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0175 | 0.7127 | 0.7127 |
Echinococcus multilocularis | serotonin transporter | 0.0089 | 0.195 | 0.195 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 230 uM | Inhibitory constant against human Carbonic anhydrase II | ChEMBL. | 15837323 |
Ki (binding) | = 230 uM | Inhibitory constant against human Carbonic anhydrase II | ChEMBL. | 15837323 |
Ki (binding) | = 303 uM | Inhibitory constant against human Carbonic anhydrase I | ChEMBL. | 15837323 |
Ki (binding) | = 303 uM | Inhibitory constant against human Carbonic anhydrase I | ChEMBL. | 15837323 |
Ki (binding) | = 315 uM | Inhibitory constant against human Carbonic anhydrase IX | ChEMBL. | 15837323 |
Ki (binding) | = 315 uM | Inhibitory constant against human Carbonic anhydrase IX | ChEMBL. | 15837323 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.