Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0026 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.3828 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0026 | 0.0179 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.3828 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0018 | 0.0078 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0018 | 0.0078 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0286 | 0.3828 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Chlamydia trachomatis | glutamine binding protein | 0.0018 | 0.0078 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0714 | 0.984 | 1 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0286 | 0.3828 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0013 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0018 | 0.0078 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0026 | 0.0179 | 0.0182 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0018 | 0.0078 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0018 | 0.0078 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.000307 Mol/L | Inhibition concentration against C6 human breast cancer cells by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) method | ChEMBL. | 16085413 |
IC50 (functional) | = 0.000614 Mol/L | Inhibition concentration against C6 human breast cancer cells by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) method | ChEMBL. | 16085413 |
IC50 (functional) | = 0.000619 Mol/L | Inhibition concentration against C6 human breast cancer cells by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) method | ChEMBL. | 16085413 |
LD50 (functional) | = 895.600000000001 mg kg-1 | Lethal dose of the compound administered intraperitonially in mice | ChEMBL. | 16085413 |
LD50 (functional) | = 976 mg kg-1 | Lethal dose of the compound administered intraperitonially in mice | ChEMBL. | 16085413 |
LD50 (functional) | = 1095.3 mg kg-1 | Lethal dose of the compound administered intraperitonially in mice | ChEMBL. | 16085413 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.