Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2095 | 0.2938 | 0.2938 |
Treponema pallidum | hexokinase (hxk) | 0.6591 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.6591 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.4135 | 0.6142 | 0.6129 |
Trypanosoma brucei | hexokinase, putative | 0.6591 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.6591 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.6591 | 1 | 0.5 |
Onchocerca volvulus | 0.6591 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase type II | 0.6591 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.2039 | 0.285 | 0.2827 |
Onchocerca volvulus | 0.6591 | 1 | 1 | |
Echinococcus granulosus | hexokinase type 2 | 0.6591 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.6591 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.6591 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2095 | 0.2938 | 0.2938 |
Loa Loa (eye worm) | hexokinase | 0.2039 | 0.285 | 0.285 |
Onchocerca volvulus | 0.6591 | 1 | 1 | |
Onchocerca volvulus | Hexokinase homolog | 0.4135 | 0.6142 | 0.6142 |
Loa Loa (eye worm) | hexokinase | 0.6591 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.6591 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.6591 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.6591 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.6591 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.6591 | 1 | 0.5 |
Onchocerca volvulus | 0.4135 | 0.6142 | 0.6142 | |
Echinococcus granulosus | hexokinase | 0.6591 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.6591 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.6591 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0245 | 0.0032 | 0.0032 |
Schistosoma mansoni | hexokinase | 0.6591 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.6591 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.6591 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.6591 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.4135 | 0.6142 | 0.6142 |
Plasmodium vivax | hexokinase, putative | 0.6591 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.6591 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4495 | 0.6708 | 0.6708 |
Loa Loa (eye worm) | hexokinase | 0.6591 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | extracellular metallopeptidase | 0.1869 | 0.2582 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.6591 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.2095 | 0.2938 | 0.2916 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 15 uM | In vitro growth inhibitory activity against Plasmodium falciparum upon incubation at 37 degrees C with compound dissolved in DMSO using [3H]-hypoxanthine (50 uL) | ChEMBL. | 16161998 |
IC50 (functional) | = 83 uM | Inhibitory constant against Trypanosoma brucei rhodesiense upon incubation with the compound at 37 degrees C under a 5% CO2 atmosphere for 72 hours | ChEMBL. | 16161998 |
IC50 (functional) | > 88 uM | In vitro growth inhibitory activity against Leishmania donovani amastigotes at 37 degrees C under a 5% CO2 atmosphere for 96 hours | ChEMBL. | 16161998 |
IC50 (functional) | > 263 uM | In vitro growth inhibitory activity against Trypanosoma cruzi in rat L-6 cells upon incubation at 37 degrees C in 5% CO2 atmosphere for 4 days | ChEMBL. | 16161998 |
IC50 (functional) | > 263 uM | In vitro cytotoxicity aganist rat skeletal myoblasts (L-6 cells) after 72 hours | ChEMBL. | 16161998 |
Ki (binding) | = 114 uM | Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolase | ChEMBL. | 16161998 |
Ki (binding) | = 119 uM | Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in E. coli BL21 (DE3) cells | ChEMBL. | 16161998 |
Ki (binding) | = 648 uM | Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in E. coli BL21 (DE3) cells | ChEMBL. | 16161998 |
SI (binding) | = 0.2 | Selectivity index for Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase defined as (Ki Human)/(Ki P. falciparum) | ChEMBL. | 16161998 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.