Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor NMDA | 0.0653 | 0.3427 | 0.1941 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0379 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0729 | 0.4373 | 0.31 |
Chlamydia trachomatis | glutamine binding protein | 0.0379 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0379 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0729 | 0.4373 | 0.1439 |
Schistosoma mansoni | glutamate receptor NMDA | 0.1024 | 0.805 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0379 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0379 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0379 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.118 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 32.1 ug ml-1 | Effective concentration of the compound dissolved in DMSO against HRV serotype 39 in OH-I cells by multiple-cycle CPE inhibition assay; spectrophotrometric | ChEMBL. | 16190752 |
EC50 (functional) | = 35.7 ug ml-1 | Effective concentration of the compound dissolved in DMSO against HRV serotype 39 in OH-I cells by multiple-cycle CPE inhibition assay; microscopic | ChEMBL. | 16190752 |
EC50 (functional) | < 72.7 ug ml-1 | Effective concentration of the compound dissolved in DMSO against HRV serotype 39 in WI-38 cells by multiple-cycle CPE inhibitionassay; microscopic | ChEMBL. | 16190752 |
EC50 (functional) | < 72.7 ug ml-1 | Effective concentration of the compound dissolved in DMSO against HRV serotype 39 in WI-38 cells by multiple-cycle CPE inhibitionassay; microscopic | ChEMBL. | 16190752 |
Toxicity (functional) | = 30 % | Percent toxicity of the compound at 10 ug/mL on OH-I cells | ChEMBL. | 16190752 |
Toxicity (functional) | = 100 % | Percent toxicity of the compound at 100 ug/mL on OH-I cells; range 50-100 % | ChEMBL. | 16190752 |
Toxicity (functional) | = 100 % | Percent toxicity of the compound at 32 ug/mL on OH-I cells; range 50-100 % | ChEMBL. | 16190752 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.