Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.1149 | 0.805 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0733 | 0.3417 | 0.1925 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0425 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1324 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0425 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0425 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0425 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0425 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0818 | 0.4364 | 0.1439 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0425 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0818 | 0.4364 | 0.3087 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Survival (functional) | = 40 % | Average percent survival of C57Bl/6 mice thymocytes from dexamethasone (5 uM) induced apoptosis at 5 uM | ChEMBL. | 16190767 |
Survival (functional) | = 40 % | Average percent survival of C57Bl/6 mice thymocytes from dexamethasone (5 uM) induced apoptosis at 5 uM | ChEMBL. | 16190767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.