TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 466.548 | Formula: C22H30N2O7S
H donors: 0 H acceptors: 4 LogP: 2.65 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1CN(CCN1S(=O)(=O)c1ccc(cc1)OCC#CC)C(=O)OC(C)(C)C
InChi: 1S/C22H30N2O7S/c1-6-8-15-30-17-9-11-18(12-10-17)32(27,28)24-14-13-23(21(26)31-22(3,4)5)16-19(24)20(25)29-7-2/h9-12,19H,7,13-16H2,1-5H3
InChiKey: MBMFLWAKTDIHHK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.1836	0.5682
Schistosoma mansoni	hypothetical protein	0.007	0.3232	0.4244
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.1836	0.1742
Echinococcus multilocularis	dro:myosuppressin receptor	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Echinococcus multilocularis	serotonin receptor	0.007	0.3232	1
Brugia malayi	GnHR receptor homolog	0.007	0.3232	1
Echinococcus granulosus	orexin receptor type 2	0.007	0.3232	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0114	0.0588
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Echinococcus granulosus	neuropeptide receptor A26	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Leishmania major	trypanothione reductase	0.0046	0.1836	0.1831
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0114	0.0468
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.007	0.3232	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.007	0.3232	0.4244
Echinococcus multilocularis	neuropeptide Y receptor	0.007	0.3232	1
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase)	0.0188	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3232	0.4244
Echinococcus granulosus	G protein coupled receptor 139	0.007	0.3232	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.007	0.3232	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3232	1
Onchocerca volvulus		0.007	0.3232	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.1206	0.3719
Brugia malayi	RE15519p	0.007	0.3232	1
Entamoeba histolytica	hypothetical protein	0.0035	0.1206	0.5214
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0114	1
Echinococcus granulosus	serotonin receptor	0.007	0.3232	1
Brugia malayi	hypothetical protein	0.007	0.3232	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.3232	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Echinococcus granulosus	neuropeptide Y receptor	0.007	0.3232	1
Schistosoma mansoni	hypothetical protein	0.007	0.3232	0.4244
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Echinococcus granulosus	fmrfamide receptor	0.007	0.3232	1
Onchocerca volvulus		0.007	0.3232	0.5
Trypanosoma brucei	trypanothione reductase	0.0046	0.1836	1
Onchocerca volvulus		0.007	0.3232	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.007	0.3232	1
Entamoeba histolytica	hypothetical protein	0.0035	0.1206	0.5214
Brugia malayi	G protein-coupled receptor	0.007	0.3232	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0114	0.0142
Schistosoma mansoni	opsin-like receptor	0.007	0.3232	0.4244
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.1206	0.3719
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.007	0.3232	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.1836	0.7954
Brugia malayi	glutathione reductase	0.0046	0.1836	0.5674
Onchocerca volvulus		0.007	0.3232	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.007	0.3232	1
Echinococcus granulosus	allatostatin A receptor	0.007	0.3232	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.007	0.3232	0.4244
Schistosoma mansoni	hypothetical protein	0.007	0.3232	0.4244
Echinococcus multilocularis	neuropeptide receptor A26	0.007	0.3232	1
Brugia malayi	Serotonin receptor	0.007	0.3232	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.007	0.3232	1
Echinococcus granulosus	neuropeptide receptor	0.007	0.3232	1
Loa Loa (eye worm)	G-protein coupled receptor	0.007	0.3232	1
Echinococcus multilocularis	fmrfamide receptor	0.007	0.3232	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0114	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.002
Leishmania major	hypothetical protein, unknown function	0.0054	0.2307	0.2302
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Loa Loa (eye worm)	G-protein coupled receptor	0.007	0.3232	1
Schistosoma mansoni	histamine h1 receptor	0.007	0.3232	0.4244
Mycobacterium tuberculosis	Probable reductase	0.0105	0.5213	0.5157
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.007	0.3232	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.007	0.3232	1
Plasmodium falciparum	thioredoxin reductase	0.0046	0.1836	1
Giardia lamblia	MRP-like ABC transporter	0.0014	0.0007	0.0571
Brugia malayi	Melatonin receptor type 1A	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Brugia malayi	Dopamine receptor protein 2	0.007	0.3232	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3232	0.4244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3232	0.4244
Schistosoma mansoni	biogenic amine receptor	0.007	0.3232	0.4244
Brugia malayi	hypothetical protein	0.007	0.3232	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.007	0.3232	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.1836	0.5674
Giardia lamblia	Multidrug resistance-associated protein 1	0.0014	0.0007	0.0571
Onchocerca volvulus		0.007	0.3232	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3232	0.4244
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.5213	0.5157
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.007	0.3232	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0114	0.0468
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.007	0.3232	0.4244
Schistosoma mansoni	hypothetical protein	0.007	0.3232	0.4244
Echinococcus granulosus	sex peptide receptor	0.007	0.3232	1
Echinococcus multilocularis	neuropeptide receptor	0.007	0.3232	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.5213	0.5157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3232	1
Schistosoma mansoni	biogenic amine receptor	0.007	0.3232	0.4244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3232	0.4244
Onchocerca volvulus		0.007	0.3232	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3232	1
Entamoeba histolytica	hypothetical protein	0.0035	0.1206	0.5214
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3232	0.4244
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Onchocerca volvulus		0.007	0.3232	0.5
Schistosoma mansoni	hypothetical protein	0.0035	0.1206	0.1579
Schistosoma mansoni	amine GPCR	0.007	0.3232	0.4244
Onchocerca volvulus		0.007	0.3232	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.007	0.3232	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0114	0.5
Loa Loa (eye worm)	glutathione reductase	0.0046	0.1836	0.5682
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.007	0.3232	0.4244
Brugia malayi	ORL1-like opioid receptor	0.007	0.3232	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.007	0.3232	0.4244
Echinococcus granulosus	g protein coupled receptor	0.007	0.3232	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3232	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0114	0.0588
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.5213	0.5157
Echinococcus multilocularis	sex peptide receptor	0.007	0.3232	1
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.1206	0.1579
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Onchocerca volvulus		0.007	0.3232	0.5
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0114	0.0468
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3232	0.4244
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0114	0.0468
Echinococcus granulosus	neuropeptide FF receptor 2	0.007	0.3232	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.5213	0.5157
Schistosoma mansoni	neuropeptide receptor	0.007	0.3232	0.4244
Brugia malayi	putative neuropeptide receptor	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Brugia malayi	hypothetical protein	0.007	0.3232	1
Schistosoma mansoni	opsin-like receptor	0.007	0.3232	0.4244
Echinococcus granulosus	g protein coupled receptor	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Brugia malayi	G-protein coupled receptor	0.007	0.3232	1
Brugia malayi	Serotonin receptor	0.007	0.3232	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0114	0.0588
Onchocerca volvulus		0.007	0.3232	0.5
Onchocerca volvulus		0.007	0.3232	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0114	0.0588
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.007	0.3232	0.4244
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0114	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3232	0.4244
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.007	0.3232	0.4244
Schistosoma mansoni	opsin-like receptor	0.007	0.3232	0.4244
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.007	0.3232	1
Onchocerca volvulus		0.007	0.3232	0.5
Brugia malayi	larval opioid receptor	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Brugia malayi	AKH receptor	0.007	0.3232	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.3232	0.4244
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3232	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.007	0.3232	1
Schistosoma mansoni	adenoreceptor	0.007	0.3232	0.4244
Echinococcus granulosus	peptide allatostatin:somatostatin	0.007	0.3232	1
Echinococcus multilocularis	g-protein coupled receptor	0.007	0.3232	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Brugia malayi	hypothetical protein	0.007	0.3232	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.007	0.3232	1
Brugia malayi	neuropeptide F receptor	0.007	0.3232	1
Brugia malayi	sulfakinin receptor protein	0.007	0.3232	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3232	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.007	0.3232	1
Echinococcus granulosus	g-protein coupled receptor	0.007	0.3232	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.007	0.3232	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.5884	0.5836
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0014	0.0007	0.002
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.1836	0.5674
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.3232	1
Echinococcus granulosus	somatostatin receptor	0.007	0.3232	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.007	0.3232	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.007	0.3232	1
Loa Loa (eye worm)	neuropeptide F receptor	0.007	0.3232	1
Entamoeba histolytica	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative	0.0054	0.2307	1
Schistosoma mansoni	amine GPCR	0.007	0.3232	0.4244
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Brugia malayi	hypothetical protein	0.007	0.3232	1
Echinococcus multilocularis	g protein coupled receptor	0.007	0.3232	1
Echinococcus granulosus	neuropeptide Y receptor	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Brugia malayi	hypothetical protein	0.007	0.3232	1
Loa Loa (eye worm)	TYRA-2 protein	0.007	0.3232	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0114	0.0468
Echinococcus granulosus	dro:myosuppressin receptor	0.007	0.3232	1
Plasmodium vivax	glutathione reductase, putative	0.0046	0.1836	1
Echinococcus granulosus	neuropeptides capa receptor	0.007	0.3232	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0114	0.0334
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.007	0.3232	0.4244
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.007	0.3232	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.007	0.3232	0.4244
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3232	1
Schistosoma mansoni	amine GPCR	0.007	0.3232	0.4244
Echinococcus granulosus	neuropeptide receptor	0.007	0.3232	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.007	0.3232	0.4244
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Toxoplasma gondii	thioredoxin reductase	0.0046	0.1836	1
Echinococcus multilocularis	serotonin receptor	0.007	0.3232	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0114	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0054	0.2307	1
Brugia malayi	follicle stimulating hormone receptor	0.007	0.3232	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.007	0.3232	0.4244
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0158	0.8311	0.8292
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3232	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.5884	0.5836
Schistosoma mansoni	neuropeptide receptor	0.007	0.3232	0.4244
Trichomonas vaginalis	conserved hypothetical protein	0.0188	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.007	0.3232	0.4244
Echinococcus granulosus	neuropeptides capa receptor	0.007	0.3232	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.5884	0.5836
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3232	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3232	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0114	0.0108
Entamoeba histolytica	hypothetical protein	0.0035	0.1206	0.5214
Loa Loa (eye worm)	neuropeptide F receptor	0.007	0.3232	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.3232	0.4244
Onchocerca volvulus	Neuropeptide F receptor homolog	0.007	0.3232	0.5
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0158	0.8311	0.8292
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Giardia lamblia	ABC transporter, putative	0.0014	0.0007	0.0571
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpB	0.0188	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Schistosoma mansoni	neuropeptide receptor	0.007	0.3232	0.4244
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Schistosoma mansoni	amine GPCR	0.007	0.3232	0.4244
Echinococcus multilocularis	somatostatin receptor	0.007	0.3232	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.007	0.3232	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0114	0.0334
Echinococcus granulosus	g protein coupled receptor	0.007	0.3232	1
Schistosoma mansoni	neuropeptide F-like receptor	0.007	0.3232	0.4244
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.007	0.3232	0.4244
Brugia malayi	hypothetical protein	0.007	0.3232	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3232	0.4244
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.007	0.3232	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.007	0.3232	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3232	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0114	0.0468
Brugia malayi	hypothetical protein	0.0035	0.1206	0.3719
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0114	0.0468
Brugia malayi	hypothetical protein	0.007	0.3232	1
Treponema pallidum	NADH oxidase	0.0016	0.0114	0.5
Onchocerca volvulus		0.007	0.3232	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.007	0.3232	1
Echinococcus multilocularis	fmrfamide receptor	0.007	0.3232	1
Brugia malayi	Thioredoxin reductase	0.0046	0.1836	0.5674
Trypanosoma cruzi	tyrosine phosphatase, putative	0.0054	0.2307	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.3232	0.4244
Echinococcus granulosus	alpha 1A adrenergic receptor	0.007	0.3232	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.007	0.3232	1
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.3232	1
Onchocerca volvulus		0.007	0.3232	0.5
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0114	0.0108
Onchocerca volvulus		0.007	0.3232	0.5
Brugia malayi	neuropeptide F receptor	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Brugia malayi	Dopamine receptor	0.007	0.3232	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3232	1
Echinococcus granulosus	hypothetical protein	0.007	0.3232	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.007	0.3232	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.007	0.3232	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0114	0.0468
Echinococcus granulosus	neuropeptide s receptor	0.007	0.3232	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.007	0.3232	0.4244
Schistosoma mansoni	neuropeptide F-like receptor	0.007	0.3232	0.4244
Brugia malayi	G-protein coupled receptor	0.007	0.3232	1
Echinococcus multilocularis	neuropeptide s receptor	0.007	0.3232	1
Echinococcus multilocularis	g protein coupled receptor	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0114	0.0108
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.007	0.3232	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.002
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.007	0.3232	1
Echinococcus multilocularis	neuropeptide receptor	0.007	0.3232	1
Echinococcus multilocularis	orexin receptor type 2	0.007	0.3232	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0114	0.0588
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0114	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.007	0.3232	1
Brugia malayi	hypothetical protein	0.007	0.3232	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.5213	0.5157
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.007	0.3232	1
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.1836	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0014	0.0007	0.0571
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3232	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.3232	1
Schistosoma mansoni	myosin xvIII	0.007	0.3232	0.4244
Schistosoma mansoni	neuropeptide receptor	0.007	0.3232	0.4244
Echinococcus multilocularis	allatostatin A receptor	0.007	0.3232	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Plasmodium falciparum	glutathione reductase	0.0046	0.1836	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.007	0.3232	0.4244
Echinococcus multilocularis	neuropeptide Y receptor	0.007	0.3232	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3232	1
Onchocerca volvulus		0.007	0.3232	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.007	0.3232	1
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0114	0.0108
Schistosoma mansoni	biogenic amine receptor	0.007	0.3232	0.4244
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.007	0.3232	1
Brugia malayi	hypothetical protein	0.007	0.3232	1
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.3232	1
Brugia malayi	Dopamine receptor protein 1	0.007	0.3232	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.5884	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.007	0.3232	1
Echinococcus multilocularis	g protein coupled receptor	0.007	0.3232	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0114	0.0468
Echinococcus granulosus	7TM GPCR rhodopsin	0.007	0.3232	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3232	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.007	0.3232	1
Schistosoma mansoni	amine GPCR	0.007	0.3232	0.4244
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Onchocerca volvulus		0.007	0.3232	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	0.3232	1
Echinococcus granulosus	7tm_1 domain containing protein	0.007	0.3232	1

Activities

Activity type	Activity value	Assay description	Source	Reference
(binding)	0	Inhibitory activity against TACE[ADAM metallopeptidase domain 17] in isolated enzyme assay	ChEMBL.	16084720

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 344116