Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0194 | 0.0194 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0074 | 0.0194 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0074 | 0.0194 | 1 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0271 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0074 | 0.0194 | 1 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0271 | 1 | 0.5 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.007 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0074 | 0.0194 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0194 | 0.0194 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 ug ml-1 | Inhibitory activity against Sortase A from Staphylococcus aureus | ChEMBL. | 16154746 |
IC50 (binding) | > 100 ug ml-1 | Inhibitory activity against Sortase A from Staphylococcus aureus | ChEMBL. | 16154746 |
MIC (functional) | > 100 ug ml-1 | Minimum inhibitory concentration against Staphylococcus aureus Newman strain | ChEMBL. | 16154746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.