Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.099 | 0.4439 | 0.3199 |
Chlamydia trachomatis | glutamine binding protein | 0.0508 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0508 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.099 | 0.4439 | 0.1439 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0889 | 0.3505 | 0.2056 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0508 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1595 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.1383 | 0.8054 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0508 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0508 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0508 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 | Number of swiss mice alive in a batch of 5 infected with multi-drug resistant Plasmodium yoelii, on day 28 after oral administration of 96 mg/kg/day dose | ChEMBL. | 16105737 |
Activity (functional) | = 0 | Number of swiss mice alive in a batch of 5 infected with multi-drug resistant Plasmodium yoelii, on day 28 after i.m. administration of 96 mg/kg/day dose | ChEMBL. | 16105737 |
Activity (functional) | = 93 % | Antimalarial activity against multi drug resistant Plasmodium yoelii nigeriensis in mouse at 96 mg/kg/day, po after 4 days | ChEMBL. | 16640340 |
Activity (functional) | = 93 % | Antimalarial activity against multi drug resistant Plasmodium yoelii nigeriensis in mouse at 96 mg/kg/day, po after 4 days | ChEMBL. | 16640340 |
Activity (functional) | = 97 % | Antimalarial activity against multi drug resistant Plasmodium yoelii nigeriensis in mouse at 96 mg/kg/day, po after 4 days | ChEMBL. | 16640340 |
Activity (functional) | = 97 % | Antimalarial activity against multi drug resistant Plasmodium yoelii nigeriensis in mouse at 96 mg/kg/day, po after 4 days | ChEMBL. | 16640340 |
Suppression (functional) | = 84 % | In vivo percentage suppression of parasitaemia in Swiss mice infected with multi-drug resistant Plasmodium yoelii following i.m. administration of 96 mg/kg/day dose on day 4 | ChEMBL. | 16105737 |
Suppression (functional) | = 86 % | In vivo percentage suppression of parasitaemia in Swiss mice infected with multi-drug resistant Plasmodium yoelii following i.m. administration of 96 mg/kg/day dose on day 4 | ChEMBL. | 16105737 |
Suppression (functional) | = 93 % | In vivo percentage suppression of parasitaemia in Swiss mice infected with multi-drug resistant Plasmodium yoelii following oral administration of 96 mg/kg/day dose on day 4 | ChEMBL. | 16105737 |
Suppression (functional) | = 97 % | In vivo percentage suppression of parasitaemia in Swiss mice infected with multi-drug resistant Plasmodium yoelii following oral administration of 96 mg/kg/day dose on day 4 | ChEMBL. | 16105737 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.