Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanocortin 4 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | multidomain scavenger receptor, putative | 0.002 | 0.0466 | 1 |
Trypanosoma brucei | ABC transporter, putative | 0.001 | 0.0059 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0466 | 0.0466 |
Loa Loa (eye worm) | doublecortin family protein | 0.002 | 0.0466 | 0.0466 |
Leishmania major | ATP-binding cassette protein subfamily G, member 4, putative | 0.001 | 0.0059 | 0.5 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0253 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0466 | 0.0466 |
Brugia malayi | Doublecortin family protein | 0.002 | 0.0466 | 0.0466 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0117 | 0.4428 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0253 | 1 | 0.5 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.002 | 0.0466 | 0.0931 |
Schistosoma mansoni | lipoxygenase | 0.0082 | 0.2996 | 0.6767 |
Schistosoma mansoni | polycystin 1-related | 0.002 | 0.0466 | 0.1052 |
Schistosoma mansoni | loxhd1 | 0.002 | 0.0466 | 0.1052 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0253 | 1 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0466 | 0.0931 |
Onchocerca volvulus | 0.0253 | 1 | 1 | |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0253 | 1 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0253 | 1 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.001 | 0.0059 | 0.0133 |
Plasmodium falciparum | LCCL domain-containing protein | 0.002 | 0.0466 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0117 | 0.4428 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0117 | 0.4428 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0253 | 1 | 1 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0466 | 0.0466 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.002 | 0.0466 | 0.0931 |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG84 | 0.001 | 0.0059 | 0.5 |
Echinococcus multilocularis | RUN | 0.002 | 0.0466 | 0.0931 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0253 | 1 | 1 |
Trypanosoma cruzi | ABC transporter, putative | 0.001 | 0.0059 | 0.5 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0253 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0466 | 0.1052 |
Brugia malayi | hypothetical protein | 0.002 | 0.0466 | 0.0466 |
Trypanosoma cruzi | ATP-binding cassette protein, putative | 0.001 | 0.0059 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily G, member 6, putative | 0.001 | 0.0059 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0466 | 0.0931 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0466 | 0.0931 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0466 | 0.0931 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0466 | 0.1052 |
Trypanosoma brucei | ATP-binding cassette protein, putative | 0.001 | 0.0059 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0253 | 1 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0253 | 1 | 0.5 |
Echinococcus granulosus | RUN | 0.002 | 0.0466 | 0.0931 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0466 | 0.1052 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 160 nM | cAMP stimulation in HEK293 cells transfected with human MC4R | ChEMBL. | 16183282 |
EC50 (functional) | = 160 nM | cAMP stimulation in HEK293 cells transfected with human MC4R | ChEMBL. | 16183282 |
Emax (functional) | = 87 % | cAMP stimulation in HEK293 cells transfected with human MC4R | ChEMBL. | 16183282 |
Emax (functional) | = 87 % | cAMP stimulation in HEK293 cells transfected with human MC4R | ChEMBL. | 16183282 |
Ki (binding) | = 82 nM | Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells | ChEMBL. | 16183282 |
Ki (binding) | = 82 nM | Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells | ChEMBL. | 16183282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.