Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1114 | 0.3218 | 0.2068 |
Echinococcus granulosus | integrin alpha 3 | 0.1129 | 0.3306 | 1 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.1114 | 0.3218 | 0.3002 |
Loa Loa (eye worm) | integrin beta-2 | 0.096 | 0.2315 | 0.1013 |
Echinococcus multilocularis | integrin alpha 3 | 0.1129 | 0.3306 | 1 |
Schistosoma mansoni | integrin alpha | 0.1473 | 0.5322 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.066 | 0.0556 | 0.1046 |
Echinococcus multilocularis | integrin beta 2 | 0.0711 | 0.0856 | 0.1088 |
Echinococcus granulosus | integrin beta 2 | 0.0711 | 0.0856 | 0.1088 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.1473 | 0.5322 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1156 | 0.3466 | 0.2358 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | < 50 % | Displacement of [125I]-LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells at 10 uM | ChEMBL. | 16302826 |
Inhibition (functional) | < 50 % | Displacement of [125I]-OVTA antagonist from human oxytocin receptor expressed in HEK293-EBNA cells at 10 uM | ChEMBL. | 16302826 |
Inhibition (functional) | < 50 % | Displacement of [125I]-LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells at 10 uM | ChEMBL. | 16302826 |
Inhibition (functional) | < 50 % | Displacement of [125I]-OVTA antagonist from human oxytocin receptor expressed in HEK293-EBNA cells at 10 uM | ChEMBL. | 16302826 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.