Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0944 | 0.1221 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1106 | 0.2811 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1422 | 0.5911 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1839 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.1106 | 0.2811 | 0.2811 |
Leishmania major | carbonic anhydrase-like protein | 0.1839 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1839 | 1 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0819 | 0 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1839 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1839 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1839 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.1839 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1422 | 0.5911 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1839 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1839 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1422 | 0.5911 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0819 | 0 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1106 | 0.2811 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1839 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1839 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 195 nM | Displacement of [3H]ZM241385 from Adenosine A2B receptor expressed in HEK cells | ChEMBL. | 16275090 |
Ki (binding) | = 195 nM | Displacement of [3H]ZM241385 from Adenosine A2B receptor expressed in HEK cells | ChEMBL. | 16275090 |
Ki (binding) | = 3300 nM | Displacement of [3H]CPX from Adenosine A1 receptor expressed in CHO cells | ChEMBL. | 16275090 |
Ki (binding) | = 3300 nM | Displacement of [3H]CPX from Adenosine A1 receptor expressed in CHO cells | ChEMBL. | 16275090 |
Ki (binding) | = 4900 nM | Displacement of [125I]AB-MECA from Adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16275090 |
Ki (binding) | = 4900 nM | Displacement of [125I]AB-MECA from Adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16275090 |
Ki (binding) | > 5000 nM | Displacement of [3H]ZM241385 from Adenosine A2A receptor expressed in HEK cells | ChEMBL. | 16275090 |
Ki (binding) | > 5000 nM | Displacement of [3H]ZM241385 from Adenosine A2A receptor expressed in HEK cells | ChEMBL. | 16275090 |
Ratio Ki (binding) | > 25 | Selectivity of adenosine A2A receptor over adenosine A2B receptor | ChEMBL. | 16275090 |
Ratio Ki (binding) | = 16 | Selectivity of adenosine A1 receptor over adenosine A2B receptor | ChEMBL. | 16275090 |
Ratio Ki (binding) | = 24 | Selectivity of adenosine A3 receptor over adenosine A2B receptor | ChEMBL. | 16275090 |
Ratio Ki (binding) | > 25 | Selectivity of adenosine A2A receptor over adenosine A2B receptor | ChEMBL. | 16275090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.