Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | chemokine (C-C motif) receptor 4 | 360 aa | 316 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.1853 | 0.4575 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.101 | 0.2384 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1853 | 0.4575 | 0.4478 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1183 | 0.2834 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.1853 | 0.4575 | 0.4478 |
Onchocerca volvulus | 0.0093 | 0 | 0.5 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1853 | 0.4575 | 0.4478 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.394 | 1 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.1011 | 0.2387 | 0.2296 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1853 | 0.4575 | 0.451 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1853 | 0.4575 | 0.4478 |
Echinococcus multilocularis | geminin | 0.0175 | 0.0213 | 0.0038 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0512 | 0.1089 | 0.3555 |
Plasmodium falciparum | carbonic anhydrase | 0.1853 | 0.4575 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1853 | 0.4575 | 0.4478 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1853 | 0.4575 | 0.4478 |
Echinococcus granulosus | carbonic anhydrase II | 0.394 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.0213 | 0.0096 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1522 | 0.3714 | 1 |
Brugia malayi | N-myristoyltransferase 2 | 0.1011 | 0.2387 | 0.2251 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1853 | 0.4575 | 0.451 |
Loa Loa (eye worm) | hypothetical protein | 0.2481 | 0.6206 | 0.6138 |
Echinococcus granulosus | geminin | 0.0175 | 0.0213 | 0.0038 |
Leishmania major | carbonic anhydrase-like protein | 0.394 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.394 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.394 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.394 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1853 | 0.4575 | 0.4478 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.1011 | 0.2387 | 0.2251 |
Echinococcus multilocularis | carbonic anhydrase | 0.1853 | 0.4575 | 0.4478 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0672 | 0.1505 | 0.5623 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1853 | 0.4575 | 0.451 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.394 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1853 | 0.4575 | 0.451 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.394 | 1 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.1011 | 0.2387 | 0.4045 |
Echinococcus multilocularis | carbonic anhydrase | 0.1853 | 0.4575 | 0.4478 |
Giardia lamblia | CDC72 | 0.1011 | 0.2387 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.1183 | 0.2834 | 0.2749 |
Loa Loa (eye worm) | hypothetical protein | 0.1853 | 0.4575 | 0.4478 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1522 | 0.3714 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.394 | 1 | 1 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.1011 | 0.2387 | 0.2251 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1183 | 0.2834 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.394 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1853 | 0.4575 | 0.4478 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.0213 | 0.0096 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1522 | 0.3714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1853 | 0.4575 | 0.4478 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1853 | 0.4575 | 0.4478 |
Echinococcus granulosus | carbonic anhydrase | 0.1853 | 0.4575 | 0.4478 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.1011 | 0.2387 | 0.5 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.1011 | 0.2387 | 0.2251 |
Schistosoma mansoni | hypothetical protein | 0.1853 | 0.4575 | 0.451 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1183 | 0.2834 | 0.0588 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.394 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 uM | Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells | ChEMBL. | 16236499 |
IC50 (binding) | = 1 uM | Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells | ChEMBL. | 16236499 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.