Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Schistosoma mansoni | memapsin-2 (A01 family) | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0159 | 0.0608 | 0.0608 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0879 | 1 | 0.5 |
Onchocerca volvulus | 0.0159 | 0.0608 | 1 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0879 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0159 | 0.0608 | 0.0608 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0495 | 0.499 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0495 | 0.499 | 1 |
Trichomonas vaginalis | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0112 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0159 | 0.0608 | 0.0608 |
Schistosoma mansoni | dihydrofolate reductase | 0.0879 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0495 | 0.499 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0879 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0608 | 0.0608 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0112 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0159 | 0.0608 | 0.0608 |
Brugia malayi | thymidylate synthase | 0.0159 | 0.0608 | 0.0608 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0879 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0879 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0159 | 0.0608 | 0.0608 |
Brugia malayi | Dihydrofolate reductase | 0.0879 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0879 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0521 | 0.5332 | 0.5332 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0495 | 0.499 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0495 | 0.499 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0879 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0495 | 0.499 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0159 | 0.0608 | 0.0608 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.285 uM | Inhibition of recombinant human BACE1 in FRET assay | ChEMBL. | 16249081 |
IC50 (binding) | = 0.285 uM | Inhibition of recombinant human BACE1 in FRET assay | ChEMBL. | 16249081 |
IC50 (functional) | > 100 uM | Inhibition of Abeta peptide production in HEK293 cells overexpressing APP751swe | ChEMBL. | 16249081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.