Detailed information for compound 34784

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.889 | Formula: C27H18ClNO5
  • H donors: 0 H acceptors: 4 LogP: 4.03 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(c2ccc(c(c2)Cl)C)C(=O)[C@@H]2[C@H]1C(OC12C(=O)c2c(C1=O)cccc2)c1ccccc1
  • InChi: 1S/C27H18ClNO5/c1-14-11-12-16(13-19(14)28)29-25(32)20-21(26(29)33)27(34-22(20)15-7-3-2-4-8-15)23(30)17-9-5-6-10-18(17)24(27)31/h2-13,20-22H,1H3/t20-,21-,22?/m0/s1
  • InChiKey: GCUYOEKSCGUNQG-LGTSYYJHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Streptococcus pyogenes serotype M18 (strain MGAS8232) Phenylalanyl-tRNA synthetase alpha chain Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B Get druggable targets OG5_127036 All targets in OG5_127036
Chlamydia trachomatis phenylalanine--tRNA ligase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Cryptosporidium parvum putative phenylalanyl-tRNA synthetase Get druggable targets OG5_127036 All targets in OG5_127036
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania donovani phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma congolense phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS Get druggable targets OG5_127036 All targets in OG5_127036
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Schistosoma japonicum ko:K01889 phenylalanyl-tRNA synthetase alpha chain [EC6.1.1.20A], putative Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma brucei gambiense phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium berghei phenylalanine--tRNA ligase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain Get druggable targets OG5_127036 All targets in OG5_127036
Brugia malayi phenylalanyl (f) trna synthetase protein 1 Get druggable targets OG5_127036 All targets in OG5_127036
Theileria parva phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania mexicana phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania braziliensis phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B Get druggable targets OG5_127036 All targets in OG5_127036
Candida albicans phenylalanyl-tRNA synthetase Get druggable targets OG5_127036 All targets in OG5_127036
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania infantum phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS Get druggable targets OG5_127036 All targets in OG5_127036
Cryptosporidium hominis phenylalanyl-trna synthetase-like protein Get druggable targets OG5_127036 All targets in OG5_127036
Babesia bovis phenylalanyl-tRNA synthetase family protein Get druggable targets OG5_127036 All targets in OG5_127036
Neospora caninum hypothetical protein Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium yoelii phenylalanyl-tRNA synthetase, putative Get druggable targets OG5_127036 All targets in OG5_127036
Candida albicans phenylalanyl-tRNA synthetase Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium knowlesi phenylalanine--tRNA ligase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans phenylalanine--tRNA ligase Phenylalanyl-tRNA synthetase alpha chain   347 aa 286 aa 29.7 %
Theileria parva phenylalanyl-tRNA synthetase, putative Phenylalanyl-tRNA synthetase alpha chain   347 aa 318 aa 24.5 %
Plasmodium yoelii Ferredoxin-fold anticodon binding domain, putative Phenylalanyl-tRNA synthetase alpha chain   347 aa 384 aa 23.7 %
Babesia bovis phenylalanine-tRNA ligase, putative Phenylalanyl-tRNA synthetase alpha chain   347 aa 349 aa 24.9 %
Plasmodium berghei phenylalanine--tRNA ligase, putative Phenylalanyl-tRNA synthetase alpha chain   347 aa 371 aa 24.3 %
Candida albicans phenylalanine--tRNA ligase Phenylalanyl-tRNA synthetase alpha chain   347 aa 286 aa 29.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0157 0.2629 1
Echinococcus granulosus neuropeptide Y receptor 0.0157 0.2629 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0157 0.2629 1
Schistosoma mansoni amine GPCR 0.0157 0.2629 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0157 0.2629 1
Schistosoma mansoni biogenic amine receptor 0.0157 0.2629 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0157 0.2629 1
Schistosoma mansoni hypothetical protein 0.0157 0.2629 1
Brugia malayi Melatonin receptor type 1A 0.0157 0.2629 1
Schistosoma mansoni amine GPCR 0.0157 0.2629 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0157 0.2629 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0157 0.2629 1
Loa Loa (eye worm) G-protein coupled receptor 0.0157 0.2629 1
Echinococcus multilocularis fmrfamide receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis serotonin receptor 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0157 0.2629 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0157 0.2629 1
Loa Loa (eye worm) neuropeptide F receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi RE15519p 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis allatostatin A receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Brugia malayi Serotonin receptor 0.0157 0.2629 1
Schistosoma mansoni opsin-like receptor 0.0157 0.2629 1
Schistosoma mansoni histamine h1 receptor 0.0157 0.2629 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0157 0.2629 1
Echinococcus multilocularis neuropeptide Y receptor 0.0157 0.2629 1
Echinococcus multilocularis nmda type glutamate receptor 0.0106 0.1194 0.3401
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni opsin-like receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0157 0.2629 1
Echinococcus multilocularis nmda type glutamate receptor 0.0083 0.056 0.0489
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis G protein coupled receptor 139 0.0157 0.2629 1
Brugia malayi AKH receptor 0.0157 0.2629 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0157 0.2629 1
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0714 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis g protein coupled receptor 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus multilocularis g protein coupled receptor 0.0157 0.2629 1
Schistosoma mansoni amine GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0157 0.2629 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0157 0.2629 1
Schistosoma mansoni neuropeptide receptor 0.0157 0.2629 1
Echinococcus multilocularis somatostatin receptor 0.0157 0.2629 1
Echinococcus granulosus orexin receptor type 2 0.0157 0.2629 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0157 0.2629 1
Brugia malayi G-protein coupled receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi GnHR receptor homolog 0.0157 0.2629 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0157 0.2629 1
Echinococcus granulosus serotonin receptor 0.0157 0.2629 1
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0088 0.0714 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0157 0.2629 0.5
Brugia malayi hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni amine GPCR 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0157 0.2629 1
Loa Loa (eye worm) neuropeptide F receptor 0.0157 0.2629 1
Echinococcus granulosus sex peptide receptor 0.0157 0.2629 1
Echinococcus multilocularis neuropeptide receptor 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi putative neuropeptide receptor NPR1 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0714 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0157 0.2629 1
Echinococcus granulosus neuropeptide receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus neuropeptide s receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0714 0.5
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.0422 1 0.5
Schistosoma mansoni adenoreceptor 0.0157 0.2629 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis neuropeptides capa receptor 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0088 0.0714 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0157 0.2629 1
Echinococcus granulosus tm gpcr rhodopsin 0.0157 0.2629 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0157 0.2629 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0157 0.2629 1
Echinococcus multilocularis neuropeptide receptor 0.0157 0.2629 1
Echinococcus granulosus g protein coupled receptor 0.0157 0.2629 1
Schistosoma mansoni myosin xvIII 0.0157 0.2629 1
Schistosoma mansoni glutamate receptor NMDA 0.009 0.0768 0.0284
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0157 0.2629 1
Schistosoma mansoni opsin-like receptor 0.0157 0.2629 1
Echinococcus granulosus G protein coupled receptor 139 0.0157 0.2629 1
Schistosoma mansoni amine GPCR 0.0157 0.2629 1
Schistosoma mansoni biogenic amine receptor 0.0157 0.2629 1
Brugia malayi neuropeptide F receptor 0.0157 0.2629 1
Echinococcus granulosus neuropeptides capa receptor 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi larval opioid receptor 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0157 0.2629 1
Echinococcus granulosus g protein coupled receptor 0.0157 0.2629 1
Echinococcus granulosus tm gpcr rhodopsin 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Echinococcus multilocularis neuropeptide s receptor 0.0157 0.2629 1
Echinococcus multilocularis neuropeptide Y receptor 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Schistosoma mansoni neuropeptide receptor 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi putative neuropeptide receptor 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0088 0.0714 0.1193
Echinococcus granulosus tachykinin peptides receptor 99D 0.0157 0.2629 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0157 0.2629 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0157 0.2629 1
Brugia malayi Serotonin receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0714 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus neuropeptide receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0088 0.0714 0.5
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0088 0.0714 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0157 0.2629 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi G-protein coupled receptor 0.0157 0.2629 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0157 0.2629 1
Echinococcus granulosus fmrfamide receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis serotonin receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) TYRA-2 protein 0.0157 0.2629 1
Brugia malayi ORL1-like opioid receptor 0.0157 0.2629 1
Schistosoma mansoni hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Brugia malayi Dopamine receptor 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus granulosus allatostatin A receptor 0.0157 0.2629 1
Echinococcus multilocularis sex peptide receptor 0.0157 0.2629 1
Brugia malayi Dopamine receptor protein 1 0.0157 0.2629 1
Schistosoma mansoni neuropeptide F-like receptor 0.0157 0.2629 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0157 0.2629 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0157 0.2629 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus nmda type glutamate receptor 0.0106 0.1194 0.3401
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0088 0.0714 0.1193
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0422 1 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0157 0.2629 1
Brugia malayi G protein-coupled receptor 0.0157 0.2629 1
Echinococcus granulosus nmda type glutamate receptor 0.0083 0.056 0.0489
Echinococcus granulosus dro:myosuppressin receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni neuropeptide F-like receptor 0.0157 0.2629 1
Echinococcus granulosus g-protein coupled receptor 0.0157 0.2629 1
Echinococcus multilocularis orexin receptor type 2 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0157 0.2629 1
Echinococcus granulosus neuropeptide receptor A26 0.0157 0.2629 1
Echinococcus granulosus neuropeptides capa receptor 0.0157 0.2629 1
Echinococcus granulosus neuropeptide Y receptor 0.0157 0.2629 1
Schistosoma mansoni biogenic amine receptor 0.0157 0.2629 1
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0063 0 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0157 0.2629 1
Loa Loa (eye worm) G-protein coupled receptor 0.0157 0.2629 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0157 0.2629 1
Schistosoma mansoni hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis fmrfamide receptor 0.0157 0.2629 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0157 0.2629 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0157 0.2629 1
Echinococcus granulosus g protein coupled receptor 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0157 0.2629 1
Brugia malayi follicle stimulating hormone receptor 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Brugia malayi hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus somatostatin receptor 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0088 0.0714 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0157 0.2629 1
Schistosoma mansoni neuropeptide receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi sulfakinin receptor protein 0.0157 0.2629 1
Echinococcus multilocularis g protein coupled receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus hypothetical protein 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0157 0.2629 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0157 0.2629 1
Echinococcus multilocularis neuropeptides capa receptor 0.0157 0.2629 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0157 0.2629 1
Brugia malayi Dopamine receptor protein 2 0.0157 0.2629 1
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0088 0.0714 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0157 0.2629 1
Brugia malayi neuropeptide F receptor 0.0157 0.2629 1
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.0422 1 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0157 0.2629 0.5
Schistosoma mansoni neuropeptide receptor 0.0157 0.2629 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus tm gpcr rhodopsin 0.0157 0.2629 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0157 0.2629 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8.3 uM Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis ChEMBL. 14980694
IC50 (binding) = 8.3 uM Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis ChEMBL. 14980694
IC50 (binding) = 13.7 uM Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus ChEMBL. 14980694
IC50 (binding) = 13.7 uM Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus ChEMBL. 14980694
IC50 (binding) > 100 uM Inhibitory activity against human phenylalanyl-tRNA synthetase was determined ChEMBL. 14980694
IC50 (binding) > 100 uM Inhibitory activity against human phenylalanyl-tRNA synthetase was determined ChEMBL. 14980694

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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