Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0588 | 0.8113 | 1 |
Onchocerca volvulus | 0.0212 | 0.2181 | 0.2181 | |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0527 | 0.714 | 1 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0234 | 0.2525 | 0.058 |
Brugia malayi | Protein kinase domain containing protein | 0.0212 | 0.2181 | 0.2181 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.2181 | 0.2181 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.8113 | 0.8113 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0212 | 0.2181 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0212 | 0.2181 | 0.2181 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0588 | 0.8113 | 1 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0234 | 0.2525 | 0.058 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0588 | 0.8113 | 0.8113 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0588 | 0.8113 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0234 | 0.2525 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0588 | 0.8113 | 0.8113 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0588 | 0.8113 | 0.8113 |
Trypanosoma brucei | prolyl endopeptidase | 0.0588 | 0.8113 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0588 | 0.8113 | 0.8113 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0212 | 0.2181 | 0.2689 |
Echinococcus granulosus | prolyl endopeptidase | 0.0588 | 0.8113 | 1 |
Onchocerca volvulus | 0.0708 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0708 | 1 | 1 |
Onchocerca volvulus | 0.0634 | 0.8836 | 0.8836 | |
Brugia malayi | Kringle domain containing protein | 0.0212 | 0.2181 | 0.2181 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0708 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0708 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0212 | 0.2181 | 0.5 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0234 | 0.2525 | 0.058 |
Leishmania major | oligopeptidase b | 0.0234 | 0.2525 | 0.058 |
Trypanosoma cruzi | oligopeptidase b | 0.0234 | 0.2525 | 0.058 |
Schistosoma mansoni | hypothetical protein | 0.0212 | 0.2181 | 0.2181 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0212 | 0.2181 | 0.2689 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0708 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0588 | 0.8113 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0234 | 0.2525 | 0.058 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0234 | 0.2525 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.02 | 0.199 | 0.199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.14 uM | Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR | ChEMBL. | 16216508 |
IC50 (functional) | = 0.14 uM | Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR | ChEMBL. | 16216508 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.