TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 267.322 | Formula: C17H17NO2
H donors: 1 H acceptors: 1 LogP: 3.89 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCCC/N=c/1\cc(O)c2c(o1)c1ccccc1cc2
InChi: 1S/C17H17NO2/c1-2-3-10-18-16-11-15(19)14-9-8-12-6-4-5-7-13(12)17(14)20-16/h4-9,11,19H,2-3,10H2,1H3/b18-16+
InChiKey: CFRWOCSRJKFPQW-FBMGVBCBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Brugia malayi	larval opioid receptor	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0033	0.0393	0.1488
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0033	0.0393	0.0393
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0078	0.1913	0.6355
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0033	0.0393	0.1517
Onchocerca volvulus		0.0033	0.0393	0.5
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0078	0.1913	0.6355
Echinococcus granulosus	sex peptide receptor	0.0033	0.0393	0.0393
Echinococcus multilocularis	neuropeptides capa receptor	0.0033	0.0393	0.0393
Brugia malayi	Serotonin receptor	0.0033	0.0393	0.1517
Echinococcus granulosus	dro:myosuppressin receptor	0.0033	0.0393	0.0393
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0033	0.0393	0.0393
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0741	0.2801
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1008	0.3887
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0393	0.1488
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0078	0.1913	0.6065
Echinococcus multilocularis	neuropeptide receptor A26	0.0033	0.0393	0.0393
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0033	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.0393	0.0393
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.0393	0.1488
Brugia malayi	RE15519p	0.0033	0.0393	0.1517
Brugia malayi	hypothetical protein	0.0033	0.0393	0.1517
Brugia malayi	hypothetical protein	0.0033	0.0393	0.1517
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Brugia malayi	G protein-coupled receptor	0.0033	0.0393	0.1517
Onchocerca volvulus		0.0033	0.0393	0.5
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0043	0.0741	1
Echinococcus granulosus	neuropeptide Y receptor	0.0033	0.0393	0.0393
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1784	0.6745
Onchocerca volvulus		0.0033	0.0393	0.5
Loa Loa (eye worm)	inositol-1	0.0043	0.0741	0.2857
Echinococcus granulosus	g protein coupled receptor	0.0033	0.0393	0.0393
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.1784	0.688
Echinococcus multilocularis	serotonin receptor	0.0033	0.0393	0.0393
Onchocerca volvulus		0.0033	0.0393	0.5
Brugia malayi	hypothetical protein	0.0033	0.0393	0.1517
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0393	0.1488
Echinococcus granulosus	allatostatin A receptor	0.0033	0.0393	0.0393
Echinococcus granulosus	neuropeptide receptor	0.0033	0.0393	0.0393
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0741	0.246
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0393	0.1488
Onchocerca volvulus		0.0033	0.0393	0.5
Brugia malayi	Melatonin receptor type 1A	0.0033	0.0393	0.1517
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.4027	0.4027
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0033	0.0393	0.1517
Echinococcus multilocularis	inositol monophosphatase 1	0.0043	0.0741	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.2593	0.2593
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0078	0.1913	0.7235
Echinococcus granulosus	transcription factor Dp 1	0.0045	0.0792	0.0792
Echinococcus multilocularis	serotonin receptor	0.0033	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Brugia malayi	AKH receptor	0.0033	0.0393	0.1517
Brugia malayi	G-protein coupled receptor	0.0033	0.0393	0.1517
Echinococcus granulosus	biogenic amine 5HT receptor	0.0033	0.0393	0.0393
Echinococcus multilocularis	neuropeptide receptor	0.0033	0.0393	0.0393
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.0393	0.0393
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0039	0.0585	0.5
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0043	0.0741	0.2857
Brugia malayi	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus multilocularis	neuropeptide Y receptor	0.0033	0.0393	0.0393
Echinococcus multilocularis	transcription factor Dp 1	0.0045	0.0792	0.0792
Schistosoma mansoni	hypothetical protein	0.004	0.0633	0.2395
Onchocerca volvulus		0.0033	0.0393	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0033	0.0393	0.1517
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.3011	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0033	0.0393	0.0393
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0033	0.0393	0.0393
Echinococcus multilocularis	neuropeptides capa receptor	0.0033	0.0393	0.0393
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.0033	0.017
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	RNA binding protein	0.0074	0.1784	0.688
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0033	0.0393	0.0393
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0033	0.0108
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0033	0.0393	0.1517
Echinococcus granulosus	fmrfamide receptor	0.0033	0.0393	0.0393
Schistosoma mansoni	hypothetical protein	0.004	0.0633	0.2395
Brugia malayi	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0033	0.0393	0.1488
Loa Loa (eye worm)	melatonin receptor type 1A	0.0033	0.0393	0.1517
Schistosoma mansoni	opsin-like receptor	0.0033	0.0393	0.1488
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus granulosus	tar DNA binding protein	0.0074	0.1784	0.1784
Schistosoma mansoni	amine GPCR	0.0033	0.0393	0.1488
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0804	0.3039
Schistosoma mansoni	neuropeptide f receptor 76f	0.0033	0.0393	0.1488
Echinococcus multilocularis	G protein coupled receptor 139	0.0033	0.0393	0.0393
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0393	0.1488
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.0393	0.1488
Echinococcus granulosus	inositol monophosphatase 1	0.0043	0.0741	0.0741
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0033	0.0393	0.1517
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.0393	0.1488
Onchocerca volvulus		0.0033	0.0393	0.5
Brugia malayi	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0033	0.0393	0.1488
Echinococcus granulosus	neuropeptide s receptor	0.0033	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Brugia malayi	CHE-14 protein	0.0042	0.0685	0.2643
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Schistosoma mansoni	neuropeptide F-like receptor	0.0033	0.0393	0.1488
Echinococcus granulosus	biogenic amine 5HT receptor	0.0033	0.0393	0.0393
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0033	0.0393	0.0393
Echinococcus multilocularis	fmrfamide receptor	0.0033	0.0393	0.0393
Brugia malayi	ORL1-like opioid receptor	0.0033	0.0393	0.1517
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0033	0.0393	0.0393
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Echinococcus multilocularis	neuropeptide receptor	0.0033	0.0393	0.0393
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0033	0.0108
Onchocerca volvulus		0.0033	0.0393	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.0393	0.0393
Brugia malayi	TAR-binding protein	0.0074	0.1784	0.688
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0033	0.0393	0.1488
Brugia malayi	Dopamine receptor protein 2	0.0033	0.0393	0.1517
Brugia malayi	RNA binding protein	0.0074	0.1784	0.688
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1784	0.6745
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0033	0.0393	0.0393
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0393	0.1488
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0685	0.0685
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.2593	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Brugia malayi	GnHR receptor homolog	0.0033	0.0393	0.1517
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0033	0.0393	0.1488
Brugia malayi	follicle stimulating hormone receptor	0.0033	0.0393	0.1517
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0393	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0033	0.0393	0.1488
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0033	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0097	0.2593	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0033	0.0393	0.0393
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0685	0.0685
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0033	0.0393	0.0393
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0393	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0685	0.2643
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0033	0.0393	0.0393
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	TYRA-2 protein	0.0033	0.0393	0.1517
Schistosoma mansoni	hypothetical protein	0.0033	0.0393	0.1488
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1784	0.6745
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0033	0.0393	0.1488
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1784	0.6745
Echinococcus multilocularis	neuropeptide Y receptor	0.0033	0.0393	0.0393
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	G-protein coupled receptor	0.0033	0.0393	0.1517
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0078	0.1913	0.7379
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.1784	0.1784
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0393	0.1488
Brugia malayi	neuropeptide F receptor	0.0033	0.0393	0.1517
Schistosoma mansoni	hypothetical protein	0.0033	0.0393	0.1488
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0033	0.0126
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.0393	0.0393
Brugia malayi	G protein-coupled receptor F59B2.13	0.0033	0.0393	0.1517
Schistosoma mansoni	amine GPCR	0.0033	0.0393	0.1488
Brugia malayi	neuropeptide F receptor	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0033	0.0393	0.1517
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0033	0.0393	0.5
Onchocerca volvulus		0.0033	0.0393	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0888	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus granulosus	neuropeptide receptor A26	0.0033	0.0393	0.0393
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.0033	0.0126
Schistosoma mansoni	hypothetical protein	0.0033	0.0393	0.1488
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0804	0.31
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus multilocularis	orexin receptor type 2	0.0033	0.0393	0.0393
Schistosoma mansoni	biogenic amine receptor	0.0033	0.0393	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Schistosoma mansoni	growth hormone secretagogue receptor	0.0033	0.0393	0.1488
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0804	0.0804
Trichomonas vaginalis	inositol monophosphatase, putative	0.0043	0.0741	1
Brugia malayi	Inositol-1	0.0043	0.0741	0.2857
Schistosoma mansoni	myosin xvIII	0.0033	0.0393	0.1488
Schistosoma mansoni	hypothetical protein	0.004	0.0633	0.2395
Brugia malayi	sulfakinin receptor protein	0.0033	0.0393	0.1517
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Schistosoma mansoni	amine GPCR	0.0033	0.0393	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0033	0.0393	0.1517
Brugia malayi	putative neuropeptide receptor	0.0033	0.0393	0.1517
Schistosoma mansoni	patched 1	0.0042	0.0685	0.2591
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0393	0.1488
Brugia malayi	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus granulosus	neuropeptide FF receptor 2	0.0033	0.0393	0.0393
Echinococcus granulosus	hypothetical protein	0.0033	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Schistosoma mansoni	hypothetical protein	0.004	0.0633	0.2395
Brugia malayi	putative neuropeptide receptor NPR1	0.0033	0.0393	0.1517
Leishmania major	hypothetical protein, conserved	0.0114	0.3155	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus granulosus	g-protein coupled receptor	0.0033	0.0393	0.0393
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0685	0.0685
Brugia malayi	G-protein coupled receptor	0.0033	0.0393	0.1517
Loa Loa (eye worm)	neuropeptide F receptor	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Schistosoma mansoni	neuropeptide F-like receptor	0.0033	0.0393	0.1488
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0804	0.0804
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0741	0.2801
Echinococcus granulosus	G protein coupled receptor 139	0.0033	0.0393	0.0393
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Echinococcus granulosus	orexin receptor type 2	0.0033	0.0393	0.0393
Schistosoma mansoni	biogenic amine receptor	0.0033	0.0393	0.1488
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0033	0.0393	0.0393
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0033	0.0393	0.0393
Echinococcus granulosus	g protein coupled receptor	0.0033	0.0393	0.0393
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0033	0.0393	0.1517
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0685	0.2643
Echinococcus granulosus	serotonin receptor	0.0033	0.0393	0.0393
Onchocerca volvulus		0.0033	0.0393	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0393	0.1488
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0033	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus multilocularis	g-protein coupled receptor	0.0033	0.0393	0.0393
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0741	0.3871
Onchocerca volvulus		0.0033	0.0393	0.5
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.2644	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0033	0.0393	0.5
Onchocerca volvulus		0.0033	0.0393	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.0393	0.0393
Schistosoma mansoni	biogenic amine receptor	0.0033	0.0393	0.1488
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0078	0.1913	0.7379
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0033	0.0126
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0393	0.1488
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0078	0.1913	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Onchocerca volvulus		0.0033	0.0393	0.5
Schistosoma mansoni	amine GPCR	0.0033	0.0393	0.1488
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0685	0.925
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.1784	0.688
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0804	0.3039
Loa Loa (eye worm)	G-protein coupled receptor	0.0033	0.0393	0.1517
Echinococcus granulosus	neuropeptides capa receptor	0.0033	0.0393	0.0393
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0033	0.0393	0.1488
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0033	0.0393	0.0393
Onchocerca volvulus		0.0033	0.0393	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0033	0.0393	0.0393
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0033	0.0393	0.0393
Schistosoma mansoni	opsin-like receptor	0.0033	0.0393	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus multilocularis	somatostatin receptor	0.0033	0.0393	0.0393
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0033	0.0393	0.1488
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0033	0.0393	0.0393
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0033	0.0393	0.0393
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.2593	1
Schistosoma mansoni	adenoreceptor	0.0033	0.0393	0.1488
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0043	0.0741	0.5
Schistosoma mansoni	histamine h1 receptor	0.0033	0.0393	0.1488
Echinococcus multilocularis	neuropeptide s receptor	0.0033	0.0393	0.0393
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.0393	0.0393
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0039	0.0585	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0033	0.0393	0.0393
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0033	0.0393	0.0393
Echinococcus granulosus	somatostatin receptor	0.0033	0.0393	0.0393
Onchocerca volvulus		0.0033	0.0393	0.5
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.4027	0.4027
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Echinococcus multilocularis	fmrfamide receptor	0.0033	0.0393	0.0393
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0804	0.31
Brugia malayi	Dopamine receptor protein 1	0.0033	0.0393	0.1517
Onchocerca volvulus		0.0033	0.0393	0.5
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0043	0.0741	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Echinococcus granulosus	7tm_1 domain containing protein	0.0033	0.0393	0.0393
Echinococcus granulosus	neuropeptides capa receptor	0.0033	0.0393	0.0393
Echinococcus granulosus	g protein coupled receptor	0.0033	0.0393	0.0393
Echinococcus multilocularis	allatostatin A receptor	0.0033	0.0393	0.0393
Brugia malayi	Serotonin receptor	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Echinococcus granulosus	7TM GPCR rhodopsin	0.0033	0.0393	0.0393
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Echinococcus multilocularis	expressed conserved protein	0.0092	0.239	0.239
Brugia malayi	hypothetical protein	0.0033	0.0393	0.1517
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0741	0.2348
Echinococcus granulosus	neuropeptide Y receptor	0.0033	0.0393	0.0393
Schistosoma mansoni	amine GPCR	0.0033	0.0393	0.1488
Echinococcus multilocularis	sex peptide receptor	0.0033	0.0393	0.0393
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0741	0.246
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0033	0.0393	0.1488
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.0393	0.0393
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0078	0.1913	0.1913
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0804	0.3039
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0033	0.0393	0.0393
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1784	0.6745
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0393	0.1488
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0033	0.0393	0.1517
Schistosoma mansoni	opsin-like receptor	0.0033	0.0393	0.1488
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0078	0.1913	0.1913
Echinococcus multilocularis	protein patched	0.0042	0.0685	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0033	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Giardia lamblia	GTOR	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Onchocerca volvulus		0.0033	0.0393	0.5
Brugia malayi	hypothetical protein	0.0033	0.0393	0.1517
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0033	0.0393	0.1517
Echinococcus granulosus	expressed conserved protein	0.0092	0.239	0.239
Echinococcus granulosus	neuropeptide receptor	0.0033	0.0393	0.0393
Schistosoma mansoni	hypothetical protein	0.0033	0.0393	0.1488
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.2593	0.2593
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0033	0.0393	0.1488
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0033	0.0393	0.1488
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0393	0.0393
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0078	0.1913	0.7379
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0393	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0393	0.1517
Brugia malayi	Dopamine receptor	0.0033	0.0393	0.1517
Brugia malayi	hypothetical protein	0.0033	0.0393	0.1517
Leishmania major	cytochrome p450-like protein	0.0023	0.0033	0.0103
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.1784	0.688
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0033	0.0393	0.1488

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10 uM	Inhibitory activity against DNA-dependent protein kinase receptor	ChEMBL.	16302822
IC50 (binding)	> 10 uM	Inhibitory activity against DNA-dependent protein kinase receptor	ChEMBL.	16302822

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 348747