Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | chemokine (C-C motif) receptor 4 | 360 aa | 316 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0042 | 0.0563 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 0.9774 | 0.9773 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.0017 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.0017 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0042 | 0.0563 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.0017 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0042 | 0.0563 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.0017 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0563 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.0017 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0025 | 0.0017 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0042 | 0.0563 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0025 | 0.0017 | 0.5 |
Onchocerca volvulus | 0.0321 | 0.9227 | 0.5 | |
Echinococcus multilocularis | protein kinase c iota type | 0.0042 | 0.0563 | 1 |
Brugia malayi | protein kinase C II. | 0.0042 | 0.0563 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.0017 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.0017 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0025 | 0.0017 | 0.5 |
Toxoplasma gondii | AGC kinase | 0.0025 | 0.0017 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.9227 | 0.9226 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.0017 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.9227 | 0.9226 |
Echinococcus granulosus | protein kinase c iota type | 0.0042 | 0.0563 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0563 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.0017 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0042 | 0.0563 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0025 | 0.0017 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.0017 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.0017 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0025 | 0.0017 | 0.5 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0042 | 0.0563 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0563 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.9227 | 0.9226 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.7 uM | Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells | ChEMBL. | 16236499 |
IC50 (binding) | = 0.7 uM | Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells | ChEMBL. | 16236499 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.