Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phospholipase A1, putative | 0.0359 | 0.5102 | 1 |
Leishmania major | phospholipase A1, putative | 0.0359 | 0.5102 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 1 | 1 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0359 | 0.5102 | 1 |
Trypanosoma brucei | phospholipase A1, putative | 0.0359 | 0.5102 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0545 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.7 uM tube-1 | Compound was evaluated for its inhibitory activity against estrone sulfatase enzyme | ChEMBL. | 11992773 |
IC50 (binding) | = 6.7 uM tube-1 | Compound was evaluated for its inhibitory activity against estrone sulfatase enzyme | ChEMBL. | 11992773 |
Inhibition (binding) | = 44.2 % | Compound was evaluated for its percent inhibition against the estrone sulfatase enzyme at a concentration of 5 microM | ChEMBL. | 11992773 |
Inhibition (binding) | = 44.2 % | Compound was evaluated for its percent inhibition against the estrone sulfatase enzyme at a concentration of 5 microM | ChEMBL. | 11992773 |
logP (ADMET) | = 3.483 | Partition coefficient (logP) | ChEMBL. | 11992773 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.