Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | phospholipase A1, putative | 2.0407 | 1 | 1 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.9358 | 0.4534 | 0.4534 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.9358 | 0.4534 | 0.4534 |
Onchocerca volvulus | 2.0407 | 1 | 0.5 | |
Trypanosoma brucei | phospholipase A1, putative | 2.0407 | 1 | 1 |
Onchocerca volvulus | 2.0407 | 1 | 0.5 | |
Onchocerca volvulus | 2.0407 | 1 | 0.5 | |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 2.0407 | 1 | 1 |
Trypanosoma cruzi | phospholipase A1, putative | 2.0407 | 1 | 1 |
Trypanosoma cruzi | phospholipase A1, putative | 2.0407 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0194 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 37 uM | Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRB | ChEMBL. | 16392826 |
IC50 (functional) | = 37 uM | Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRB | ChEMBL. | 16392826 |
IC50 (binding) | > 100 uM | Inhibitory activity against human B-RAF | ChEMBL. | 16392826 |
IC50 (binding) | > 100 uM | Inhibitory activity against human B-RAF | ChEMBL. | 16392826 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.