Detailed information for compound 351181

Basic information

Technical information
  • TDR Targets ID: 351181
  • Name: 2-(7-chloroquinolin-4-yl)-5-(4-methylphenyl)- 3-(trifluoromethyl)-4H-pyrazol-3-ol
  • MW: 405.801 | Formula: C20H15ClF3N3O
  • H donors: 1 H acceptors: 2 LogP: 5.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C1=NN(C(C1)(O)C(F)(F)F)c1ccnc2c1ccc(c2)Cl
  • InChi: 1S/C20H15ClF3N3O/c1-12-2-4-13(5-3-12)17-11-19(28,20(22,23)24)27(26-17)18-8-9-25-16-10-14(21)6-7-15(16)18/h2-10,28H,11H2,1H3
  • InChiKey: QNPSRZTVXGKJAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(7-chloro-4-quinolyl)-5-(p-tolyl)-3-(trifluoromethyl)-4H-pyrazol-3-ol
  • 2-(7-chloro-4-quinolyl)-5-(p-tolyl)-3-(trifluoromethyl)-2-pyrazolin-3-ol
  • 2-(7-chloro-4-quinolyl)-5-(4-methylphenyl)-3-(trifluoromethyl)-4H-pyrazol-3-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0173317 0.108798 0.18924
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.00830578 0.0202691 1
Schistosoma mansoni amine GPCR 0.0173317 0.108798 0.18924
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0173317 0.108798 0.18924
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Onchocerca volvulus 0.0173317 0.108798 1
Brugia malayi hypothetical protein 0.0173317 0.108798 0.193165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173317 0.108798 0.18924
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173317 0.108798 0.193165
Loa Loa (eye worm) neuropeptide F receptor 0.0173317 0.108798 0.197955
Echinococcus granulosus rhodopsin orphan GPCR 0.0173317 0.108798 0.0924688
Onchocerca volvulus 0.0173317 0.108798 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0173317 0.108798 0.18924
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.00830578 0.0202691 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019638 0.131419 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0173317 0.108798 0.193165
Brugia malayi Serotonin receptor 0.0173317 0.108798 0.193165
Echinococcus granulosus neuropeptides capa receptor 0.0173317 0.108798 0.0924688
Brugia malayi neuropeptide F receptor 0.0173317 0.108798 0.193165
Echinococcus granulosus g protein coupled receptor 0.0173317 0.108798 0.0924688
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0173317 0.108798 0.193165
Schistosoma mansoni amine GPCR 0.0173317 0.108798 0.18924
Schistosoma mansoni biogenic amine (5HT) receptor 0.0173317 0.108798 0.18924
Onchocerca volvulus Neuropeptide F receptor homolog 0.0173317 0.108798 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0560016 0.488084 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Schistosoma mansoni biogenic amine receptor 0.0173317 0.108798 0.18924
Schistosoma mansoni neuropeptide F-like receptor 0.0173317 0.108798 0.18924
Echinococcus granulosus peptide allatostatin:somatostatin 0.0173317 0.108798 0.0924688
Brugia malayi G protein-coupled receptor F59B2.13 0.0173317 0.108798 0.193165
Onchocerca volvulus 0.0173317 0.108798 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173317 0.108798 0.18924
Schistosoma mansoni growth hormone secretagogue receptor 0.0173317 0.108798 0.18924
Echinococcus granulosus tm gpcr rhodopsin 0.0173317 0.108798 0.0924688
Brugia malayi G-protein coupled receptor 0.0173317 0.108798 0.193165
Echinococcus granulosus tm gpcr rhodopsin 0.0173317 0.108798 0.0924688
Schistosoma mansoni neuropeptide receptor 0.0173317 0.108798 0.18924
Onchocerca volvulus 0.0173317 0.108798 1
Echinococcus multilocularis neuropeptide receptor 0.0173317 0.108798 0.193165
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.00807376 0.0179934 0.0299949
Echinococcus multilocularis dro:myosuppressin receptor 0.0173317 0.108798 0.193165
Echinococcus granulosus 7tm_1 domain containing protein 0.0173317 0.108798 0.0924688
Echinococcus granulosus rhodopsin orphan GPCR 0.0173317 0.108798 0.0924688
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0173317 0.108798 0.0924688
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.00830578 0.0202691 0.00231743
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00830578 0.0202691 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0173317 0.108798 0.18924
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173317 0.108798 0.18924
Schistosoma mansoni neuropeptide receptor 0.0173317 0.108798 0.18924
Schistosoma mansoni amine GPCR 0.0173317 0.108798 0.18924
Echinococcus granulosus somatostatin receptor 0.0173317 0.108798 0.0924688
Echinococcus multilocularis neuropeptide FF receptor 2 0.0173317 0.108798 0.193165
Schistosoma mansoni biogenic amine receptor 0.0173317 0.108798 0.18924
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0173317 0.108798 0.193165
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0173317 0.108798 0.0924688
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0173317 0.108798 0.193165
Echinococcus multilocularis fmrfamide receptor 0.0173317 0.108798 0.193165
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus granulosus allatostatin A receptor 0.0173317 0.108798 0.0924688
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus multilocularis neuropeptide receptor A26 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus multilocularis neuropeptide receptor 0.0173317 0.108798 0.193165
Onchocerca volvulus 0.0173317 0.108798 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus multilocularis fmrfamide receptor 0.0173317 0.108798 0.193165
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus granulosus neuropeptide Y receptor 0.0173317 0.108798 0.0924688
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Onchocerca volvulus 0.0173317 0.108798 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.019638 0.131419 0.115504
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0173317 0.108798 0.197955
Echinococcus granulosus 7TM GPCR rhodopsin 0.0173317 0.108798 0.0924688
Echinococcus multilocularis allatostatin A receptor 0.0173317 0.108798 0.193165
Echinococcus multilocularis adenylate cyclase type IX 0.0113685 0.0503088 0.0687429
Echinococcus multilocularis orexin receptor type 2 0.0173317 0.108798 0.193165
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0173317 0.108798 0.18924
Brugia malayi putative neuropeptide receptor NPR1 0.0173317 0.108798 0.193165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173317 0.108798 0.18924
Echinococcus granulosus rhodopsin orphan GPCR 0.0173317 0.108798 0.0924688
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0173317 0.108798 0.193165
Brugia malayi G protein-coupled receptor 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus granulosus g protein coupled receptor 0.0173317 0.108798 0.0924688
Echinococcus granulosus biogenic amine 5HT receptor 0.0173317 0.108798 0.0924688
Schistosoma mansoni biogenic amine (5HT) receptor 0.0173317 0.108798 0.18924
Echinococcus multilocularis g protein coupled receptor 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Loa Loa (eye worm) G-protein coupled receptor 0.0173317 0.108798 0.197955
Schistosoma mansoni histamine h1 receptor 0.0173317 0.108798 0.18924
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0173317 0.108798 0.0924688
Schistosoma mansoni alpha-1 adrenergic receptor 0.0173317 0.108798 0.18924
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Schistosoma mansoni neuropeptide f receptor 76f 0.0173317 0.108798 0.18924
Echinococcus multilocularis g protein coupled receptor 0.0173317 0.108798 0.193165
Echinococcus granulosus neuropeptide receptor 0.0173317 0.108798 0.0924688
Echinococcus granulosus neuropeptide receptor 0.0173317 0.108798 0.0924688
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.00830578 0.0202691 0.154233
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Brugia malayi Serotonin receptor 0.0173317 0.108798 0.193165
Schistosoma mansoni adenoreceptor 0.0173317 0.108798 0.18924
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0173317 0.108798 0.18924
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.019638 0.131419 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0173317 0.108798 0.197955
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Schistosoma mansoni opsin-like receptor 0.0173317 0.108798 0.18924
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0173317 0.108798 0.18924
Schistosoma mansoni neuropeptide receptor 0.0173317 0.108798 0.18924
Loa Loa (eye worm) hypothetical protein 0.00807376 0.0179934 0.00593765
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00830578 0.0202691 1
Onchocerca volvulus 0.0173317 0.108798 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Onchocerca volvulus 0.0173317 0.108798 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173317 0.108798 0.18924
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173317 0.108798 0.193165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173317 0.108798 0.18924
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0173317 0.108798 0.197955
Schistosoma mansoni amine GPCR 0.0173317 0.108798 0.18924
Echinococcus granulosus rhodopsin orphan GPCR 0.0173317 0.108798 0.0924688
Echinococcus granulosus neuropeptides capa receptor 0.0173317 0.108798 0.0924688
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.00830578 0.0202691 0.00484104
Onchocerca volvulus 0.0173317 0.108798 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus multilocularis somatostatin receptor 0.0173317 0.108798 0.193165
Echinococcus granulosus alpha 1A adrenergic receptor 0.0173317 0.108798 0.0924688
Schistosoma mansoni amine GPCR 0.0173317 0.108798 0.18924
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.00830578 0.0202691 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0173317 0.108798 0.0924688
Loa Loa (eye worm) PDE1B protein 0.0560016 0.488084 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0560016 0.488084 1
Brugia malayi hypothetical protein 0.0173317 0.108798 0.193165
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.019638 0.131419 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0173317 0.108798 0.193165
Echinococcus multilocularis neuropeptides capa receptor 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Brugia malayi hypothetical protein 0.0173317 0.108798 0.193165
Onchocerca volvulus 0.0173317 0.108798 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Loa Loa (eye worm) G-protein coupled receptor 0.0173317 0.108798 0.197955
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019638 0.131419 0.5
Brugia malayi GnHR receptor homolog 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0173317 0.108798 0.193165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173317 0.108798 0.193165
Echinococcus multilocularis neuropeptides capa receptor 0.0173317 0.108798 0.193165
Schistosoma mansoni myosin xvIII 0.0173317 0.108798 0.18924
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0173317 0.108798 0.193165
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus granulosus neuropeptide Y receptor 0.0173317 0.108798 0.0924688
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0560016 0.488084 1
Brugia malayi larval opioid receptor 0.0173317 0.108798 0.193165
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus granulosus dro:myosuppressin receptor 0.0173317 0.108798 0.0924688
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0173317 0.108798 0.197955
Loa Loa (eye worm) TYRA-2 protein 0.0173317 0.108798 0.197955
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus granulosus neuropeptide s receptor 0.0173317 0.108798 0.0924688
Echinococcus multilocularis sex peptide receptor 0.0173317 0.108798 0.193165
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.00830578 0.0202691 0.154233
Brugia malayi neuropeptide F receptor 0.0173317 0.108798 0.193165
Brugia malayi hypothetical protein 0.0173317 0.108798 0.193165
Brugia malayi hypothetical protein 0.0173317 0.108798 0.193165
Onchocerca volvulus 0.0173317 0.108798 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Schistosoma mansoni hypothetical protein 0.0173317 0.108798 0.18924
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Onchocerca volvulus 0.0173317 0.108798 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0173317 0.108798 0.193165
Echinococcus multilocularis G-protein coupled receptor, putative 0.0173317 0.108798 0.193165
Onchocerca volvulus 0.0173317 0.108798 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0173317 0.108798 0.197955
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0173317 0.108798 0.18924
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173317 0.108798 0.193165
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.019638 0.131419 1
Onchocerca volvulus 0.00807376 0.0179934 0.0299949
Brugia malayi RE15519p 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus granulosus G protein coupled receptor 139 0.0173317 0.108798 0.0924688
Echinococcus granulosus fmrfamide receptor 0.0173317 0.108798 0.0924688
Onchocerca volvulus 0.0173317 0.108798 1
Loa Loa (eye worm) adenylyl cyclase 3 0.0191559 0.126691 0.235791
Echinococcus multilocularis neuropeptide Y receptor 0.0173317 0.108798 0.193165
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.019638 0.131419 1
Echinococcus granulosus tm gpcr rhodopsin 0.0173317 0.108798 0.0924688
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173317 0.108798 0.18924
Schistosoma mansoni biogenic amine receptor 0.0173317 0.108798 0.18924
Brugia malayi Dopamine receptor protein 2 0.0173317 0.108798 0.193165
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173317 0.108798 0.193165
Echinococcus granulosus orexin receptor type 2 0.0173317 0.108798 0.0924688
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0333592 0.266001 0.527573
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0560016 0.488084 0.478704
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0173317 0.108798 0.193165
Brugia malayi hypothetical protein 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Trichomonas vaginalis conserved hypothetical protein 0.00830578 0.0202691 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus granulosus g-protein coupled receptor 0.0173317 0.108798 0.0924688
Echinococcus multilocularis neuropeptide s receptor 0.0173317 0.108798 0.193165
Onchocerca volvulus 0.0173317 0.108798 1
Loa Loa (eye worm) neuropeptide F receptor 0.0173317 0.108798 0.197955
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Brugia malayi sulfakinin receptor protein 0.0173317 0.108798 0.193165
Schistosoma mansoni neuropeptide receptor 0.0173317 0.108798 0.18924
Echinococcus multilocularis serotonin receptor 0.0173317 0.108798 0.193165
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00830578 0.0202691 1
Schistosoma mansoni opsin-like receptor 0.0173317 0.108798 0.18924
Brugia malayi AKH receptor 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus granulosus rhodopsin orphan GPCR 0.0173317 0.108798 0.0924688
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus granulosus neuropeptide receptor A26 0.0173317 0.108798 0.0924688
Schistosoma mansoni opsin-like receptor 0.0173317 0.108798 0.18924
Brugia malayi ORL1-like opioid receptor 0.0173317 0.108798 0.193165
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0173317 0.108798 0.18924
Onchocerca volvulus 0.0173317 0.108798 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.019638 0.131419 0.241284
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.019638 0.131419 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173317 0.108798 0.193165
Echinococcus multilocularis g-protein coupled receptor 0.0173317 0.108798 0.193165
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0173317 0.108798 0.193165
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.00830578 0.0202691 1
Schistosoma mansoni hypothetical protein 0.0173317 0.108798 0.18924
Brugia malayi Melatonin receptor type 1A 0.0173317 0.108798 0.193165
Echinococcus granulosus hypothetical protein 0.0173317 0.108798 0.0924688
Echinococcus granulosus neuropeptide FF receptor 2 0.0173317 0.108798 0.0924688
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0173317 0.108798 0.193165
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0173317 0.108798 0.0924688
Brugia malayi hypothetical protein 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Loa Loa (eye worm) melatonin receptor type 1A 0.0173317 0.108798 0.197955
Schistosoma mansoni hypothetical protein 0.0173317 0.108798 0.18924
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0173317 0.108798 0.193165
Brugia malayi follicle stimulating hormone receptor 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0173317 0.108798 0.18924
Echinococcus multilocularis serotonin receptor 0.0173317 0.108798 0.193165
Echinococcus granulosus serotonin receptor 0.0173317 0.108798 0.0924688
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0173317 0.108798 0.0924688
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0173317 0.108798 0.18924
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173317 0.108798 0.18924
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173317 0.108798 0.193165
Brugia malayi Tachykinin-like peptides receptor 99D 0.0173317 0.108798 0.193165
Echinococcus multilocularis neuropeptide Y receptor 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Echinococcus granulosus tachykinin peptides receptor 99D 0.0333592 0.266001 0.252551
Schistosoma mansoni hypothetical protein 0.0173317 0.108798 0.18924
Echinococcus granulosus rhodopsin orphan GPCR 0.0173317 0.108798 0.0924688
Brugia malayi hypothetical protein 0.0173317 0.108798 0.193165
Echinococcus granulosus g protein coupled receptor 0.0173317 0.108798 0.0924688
Echinococcus granulosus adenylate cyclase type IX 0.0113685 0.0503088 0.0329075
Brugia malayi hypothetical protein 0.0173317 0.108798 0.193165
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.00830578 0.0202691 0.154233
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0173317 0.108798 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0173317 0.108798 0.193165
Brugia malayi Dopamine receptor protein 1 0.0173317 0.108798 0.193165
Echinococcus multilocularis G protein coupled receptor 139 0.0173317 0.108798 0.193165
Echinococcus granulosus biogenic amine 5HT receptor 0.0173317 0.108798 0.0924688
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0173317 0.108798 0.18924
Echinococcus granulosus rhodopsin orphan GPCR 0.0173317 0.108798 0.0924688
Schistosoma mansoni neuropeptide F-like receptor 0.0173317 0.108798 0.18924
Brugia malayi G-protein coupled receptor 0.0173317 0.108798 0.193165
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.00807376 0.0179934 0.0299949
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.00830578 0.0202691 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173317 0.108798 0.193165
Echinococcus granulosus sex peptide receptor 0.0173317 0.108798 0.0924688
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173317 0.108798 0.18924
Onchocerca volvulus 0.0173317 0.108798 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Brugia malayi hypothetical protein 0.0173317 0.108798 0.193165
Brugia malayi Dopamine receptor 0.0173317 0.108798 0.193165
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0173317 0.108798 0.18924
Echinococcus granulosus Solute carrier family 22 5 0.108194 1 1
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0173317 0.108798 0.193165
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0173317 0.108798 0.193165
Brugia malayi putative neuropeptide receptor 0.0173317 0.108798 0.193165
Echinococcus multilocularis g protein coupled receptor 0.0173317 0.108798 0.193165
Loa Loa (eye worm) hypothetical protein 0.0173317 0.108798 0.197955

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.04 ug ml-1 Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 clone cultured in human RBC ChEMBL. 16257205
IC50 (functional) = 3.04 ug ml-1 Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 clone cultured in human RBC ChEMBL. 16257205

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 16257205

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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