Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0797 | 0.3632 | 0.3632 |
Echinococcus granulosus | dihydrofolate reductase | 0.1978 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0797 | 0.3632 | 0.3632 |
Onchocerca volvulus | 0.0124 | 0 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0797 | 0.3632 | 0.3632 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0912 | 0.4249 | 1 |
Brugia malayi | P38 map kinase family protein 2 | 0.0797 | 0.3632 | 0.3632 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1978 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1978 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1978 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0797 | 0.3632 | 0.3632 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0912 | 0.4249 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1978 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1978 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1978 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0912 | 0.4249 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0912 | 0.4249 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0797 | 0.3632 | 0.3632 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0797 | 0.3632 | 0.3632 |
Schistosoma mansoni | dihydrofolate reductase | 0.1978 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0912 | 0.4249 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1978 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0912 | 0.4249 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0797 | 0.3632 | 0.3632 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 9.6 nM | Binding affinity to human cloned dopamine D3 receptor | ChEMBL. | 16271293 |
Ki (binding) | = 9.6 nM | Binding affinity to human cloned dopamine D3 receptor | ChEMBL. | 16271293 |
Ki (binding) | = 83 nM | Binding affinity to human cloned dopamine D2 receptor | ChEMBL. | 16271293 |
Ki (binding) | = 83 nM | Binding affinity to human cloned dopamine D2 receptor | ChEMBL. | 16271293 |
Ratio Ki (binding) | = 9 | Selectivity for human cloned dopamine D3 receptor over D2 receptor | ChEMBL. | 16271293 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.