Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pyogenes serotype M18 (strain MGAS8232) | Phenylalanyl-tRNA synthetase alpha chain | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium yoelii | Ferredoxin-fold anticodon binding domain, putative | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 384 aa | 23.7 % |
Babesia bovis | phenylalanine-tRNA ligase, putative | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 349 aa | 24.9 % |
Candida albicans | phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 286 aa | 29.7 % |
Theileria parva | phenylalanyl-tRNA synthetase, putative | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 318 aa | 24.5 % |
Plasmodium berghei | phenylalanine--tRNA ligase, putative | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 371 aa | 24.3 % |
Candida albicans | phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase alpha chain | 347 aa | 286 aa | 29.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | phenylalanine--tRNA ligase subunit alpha | 0.0422 | 0.5464 | 0.5 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0422 | 0.5464 | 1 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0088 | 0 | 0.5 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0088 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0172 | 0.1362 | 0.1362 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0088 | 0 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0699 | 1 | 1 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0088 | 0 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0699 | 1 | 1 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0 | 0.5 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0 | 0.5 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.0422 | 0.5464 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0 | 0.5 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1362 | 0.1362 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0088 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1362 | 0.1362 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0088 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0172 | 0.1362 | 0.1362 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.0422 | 0.5464 | 0.5 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0088 | 0 | 0.5 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0088 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus | ChEMBL. | 14980694 |
IC50 (binding) | = 13 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus | ChEMBL. | 14980694 |
IC50 (binding) | = 57 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis | ChEMBL. | 14980694 |
IC50 (binding) | = 57 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis | ChEMBL. | 14980694 |
IC50 (binding) | > 100 uM | Inhibitory activity against human phenylalanyl-tRNA synthetase was determined | ChEMBL. | 14980694 |
IC50 (binding) | > 100 uM | Inhibitory activity against human phenylalanyl-tRNA synthetase was determined | ChEMBL. | 14980694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.