Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0093 | 0.1111 | 0.1111 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.3003 | 0.3003 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0093 | 0.1111 | 0.1111 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0331 | 0.0331 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0093 | 0.1111 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0191 | 0.3041 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0191 | 0.3041 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0191 | 0.3041 | 0.3041 |
Brugia malayi | hypothetical protein | 0.0131 | 0.1854 | 0.4199 |
Plasmodium falciparum | protein kinase 5 | 0.0093 | 0.1111 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0191 | 0.3041 | 0.6889 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1854 | 0.1854 |
Entamoeba histolytica | protein kinase, putative | 0.0191 | 0.3041 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0191 | 0.3041 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0093 | 0.1111 | 0.2517 |
Plasmodium vivax | protein kinase Crk2 | 0.0093 | 0.1111 | 0.5 |
Brugia malayi | hypothetical protein | 0.0261 | 0.4415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.4415 | 0.4415 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0546 | 1 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0191 | 0.3041 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0191 | 0.3041 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0191 | 0.3041 | 0.3041 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0191 | 0.3041 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.1111 | 0.1111 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0093 | 0.1111 | 0.1111 |
Echinococcus multilocularis | dual specificity | 0.0191 | 0.3041 | 0.2171 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.4415 | 0.4415 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0093 | 0.1111 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0331 | 0.0749 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0093 | 0.1111 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0191 | 0.3041 | 0.2171 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0331 | 0.0331 |
Onchocerca volvulus | Huntingtin homolog | 0.0131 | 0.1854 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0191 | 0.3041 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0093 | 0.1111 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0093 | 0.1111 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.3003 | 0.3003 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1854 | 0.1854 |
Giardia lamblia | Kinase, CMGC CDK | 0.0093 | 0.1111 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0331 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1073 | 0.1073 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.1111 | 0.1111 |
Onchocerca volvulus | Huntingtin homolog | 0.0131 | 0.1854 | 0.5 |
Brugia malayi | cell division control protein 2 homolog | 0.0093 | 0.1111 | 0.2517 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0546 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Antiviral activity against HIV1 in human PBMC | ChEMBL. | 16509580 |
EC90 (functional) | > 100 uM | Antiviral activity against HIV1 in human PBMC | ChEMBL. | 16509580 |
IC50 (functional) | > 100 uM | Cytotoxicity against human PBMC | ChEMBL. | 16509580 |
IC50 (functional) | > 100 uM | Cytotoxicity against human CEM cells | ChEMBL. | 16509580 |
IC50 (functional) | > 100 uM | Cytotoxicity against Vero cells | ChEMBL. | 16509580 |
IC50 (functional) | > 100 uM | Cytotoxicity against human PBMC | ChEMBL. | 16509580 |
IC50 (functional) | > 100 uM | Cytotoxicity against human CEM cells | ChEMBL. | 16509580 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.