Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin D (A01 family) | 0.1419 | 1 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0403 | 0.2076 | 0.2076 |
Plasmodium vivax | aspartyl protease, putative | 0.0383 | 0.1921 | 0.9257 |
Echinococcus granulosus | kinesin family 1 | 0.1052 | 0.7134 | 1 |
Giardia lamblia | Kinesin-5 | 0.0137 | 0 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0383 | 0.1921 | 0.9257 |
Plasmodium falciparum | plasmepsin IX | 0.0383 | 0.1921 | 0.9257 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0776 | 0.4985 | 0.5751 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0403 | 0.2076 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0776 | 0.4985 | 0.5751 |
Plasmodium falciparum | plasmepsin X | 0.0383 | 0.1921 | 0.9257 |
Entamoeba histolytica | kinesin, putative | 0.0137 | 0 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0383 | 0.1921 | 0.9257 |
Plasmodium falciparum | plasmepsin IV | 0.0403 | 0.2076 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.2076 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0403 | 0.2076 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0403 | 0.2076 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0403 | 0.2076 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0137 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.0403 | 0.2076 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0403 | 0.2076 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0403 | 0.2076 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0403 | 0.2076 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.1052 | 0.7134 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0403 | 0.2076 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0758 | 0.4846 | 0.4846 |
Schistosoma mansoni | tyrosine kinase | 0.0776 | 0.4985 | 0.4985 |
Schistosoma mansoni | hypothetical protein | 0.0915 | 0.6069 | 0.6069 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MEC (functional) | = 2.5 ug ml-1 | Inhibition of pseudomycelium formation of Candida albicans. | ChEMBL. | 3302257 |
MIC (functional) | = 0.8 ug ml-1 | Minimum inhibitory concentration against Trichophyton asteroides | ChEMBL. | 3302257 |
MIC (functional) | > 100 ug ml-1 | Minimum inhibitory concentration (MIC) against Candida albicans | ChEMBL. | 3302257 |
MIC (functional) | > 100 ug ml-1 | Minimum inhibitory concentration (MIC) against Aspergillus fumigatus | ChEMBL. | 3302257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.