Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0488 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0692 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0526 | 0.1851 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0692 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0488 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0488 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0488 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0488 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0488 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | <= 0.05 ug ml-1 | Antibacterial activity against Enterococcus faecalis 29212 | ChEMBL. | 16509588 |
MIC (functional) | <= 0.05 ug ml-1 | Antibacterial activity against Streptococcus pyogenes 8668 | ChEMBL. | 16509588 |
MIC (functional) | <= 0.05 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae 49619 | ChEMBL. | 16509588 |
MIC (functional) | <= 0.05 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae 297-749 | ChEMBL. | 16509588 |
MIC (functional) | <= 0.05 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae 280-962 | ChEMBL. | 16509588 |
MIC (functional) | = 0.1 ug ml-1 | Antibacterial activity against Staphylococcus aureus 29213 | ChEMBL. | 16509588 |
MIC (functional) | = 0.1 ug ml-1 | Antibacterial activity against Staphylococcus epidermidis f50654 | ChEMBL. | 16509588 |
MIC (functional) | = 0.1 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae Mef S 3427 | ChEMBL. | 16509588 |
MIC (functional) | = 0.2 ug ml-1 | Antibacterial activity against Staphylococcus epidermidis 14990 | ChEMBL. | 16509588 |
MIC (functional) | = 0.4 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae Erm 6849 | ChEMBL. | 16509588 |
MIC (functional) | = 0.78 ug ml-1 | Antibacterial activity against Enterococcus faecalis bc11148-2 | ChEMBL. | 16509588 |
MIC (functional) | = 0.78 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae Mef 5654 | ChEMBL. | 16509588 |
MIC (functional) | = 0.78 ug ml-1 | Antibacterial activity against Haemophilus influenzae 2762 | ChEMBL. | 16509588 |
MIC (functional) | = 6.25 ug ml-1 | Antibacterial activity against Haemophilus influenzae 49247 | ChEMBL. | 16509588 |
MIC (functional) | > 50 ug ml-1 | Antibacterial activity against Staphylococcus aureus 33591 | ChEMBL. | 16509588 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.