Detailed information for compound 35428

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.889 | Formula: C27H18ClNO5
  • H donors: 0 H acceptors: 4 LogP: 4.03 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(c2ccc(c(c2)Cl)C)C(=O)[C@H]2[C@@H]1C(OC12C(=O)c2c(C1=O)cccc2)c1ccccc1
  • InChi: 1S/C27H18ClNO5/c1-14-11-12-16(13-19(14)28)29-25(32)20-21(26(29)33)27(34-22(20)15-7-3-2-4-8-15)23(30)17-9-5-6-10-18(17)24(27)31/h2-13,20-22H,1H3/t20-,21-,22?/m1/s1
  • InChiKey: GCUYOEKSCGUNQG-JAZPPYFYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Streptococcus pyogenes serotype M18 (strain MGAS8232) Phenylalanyl-tRNA synthetase alpha chain Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium berghei phenylalanine--tRNA ligase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania infantum phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma brucei gambiense phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania braziliensis phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Cryptosporidium parvum putative phenylalanyl-tRNA synthetase Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Babesia bovis phenylalanyl-tRNA synthetase family protein Get druggable targets OG5_127036 All targets in OG5_127036
Brugia malayi phenylalanyl (f) trna synthetase protein 1 Get druggable targets OG5_127036 All targets in OG5_127036
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Candida albicans phenylalanyl-tRNA synthetase Get druggable targets OG5_127036 All targets in OG5_127036
Cryptosporidium hominis phenylalanyl-trna synthetase-like protein Get druggable targets OG5_127036 All targets in OG5_127036
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative Get druggable targets OG5_127036 All targets in OG5_127036
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain Get druggable targets OG5_127036 All targets in OG5_127036
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS Get druggable targets OG5_127036 All targets in OG5_127036
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B Get druggable targets OG5_127036 All targets in OG5_127036
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania donovani phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Neospora caninum hypothetical protein Get druggable targets OG5_127036 All targets in OG5_127036
Candida albicans phenylalanyl-tRNA synthetase Get druggable targets OG5_127036 All targets in OG5_127036
Chlamydia trachomatis phenylalanine--tRNA ligase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania mexicana phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium yoelii phenylalanyl-tRNA synthetase, putative Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS Get druggable targets OG5_127036 All targets in OG5_127036
Schistosoma japonicum ko:K01889 phenylalanyl-tRNA synthetase alpha chain [EC6.1.1.20A], putative Get druggable targets OG5_127036 All targets in OG5_127036
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127036 All targets in OG5_127036
Plasmodium knowlesi phenylalanine--tRNA ligase alpha subunit, putative Get druggable targets OG5_127036 All targets in OG5_127036
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Theileria parva phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha Get druggable targets OG5_127036 All targets in OG5_127036
Trypanosoma congolense phenylalanyl-tRNA synthetase alpha chain, putative Get druggable targets OG5_127036 All targets in OG5_127036
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans phenylalanine--tRNA ligase Phenylalanyl-tRNA synthetase alpha chain   347 aa 286 aa 29.7 %
Theileria parva phenylalanyl-tRNA synthetase, putative Phenylalanyl-tRNA synthetase alpha chain   347 aa 318 aa 24.5 %
Plasmodium yoelii Ferredoxin-fold anticodon binding domain, putative Phenylalanyl-tRNA synthetase alpha chain   347 aa 384 aa 23.7 %
Babesia bovis phenylalanine-tRNA ligase, putative Phenylalanyl-tRNA synthetase alpha chain   347 aa 349 aa 24.9 %
Plasmodium berghei phenylalanine--tRNA ligase, putative Phenylalanyl-tRNA synthetase alpha chain   347 aa 371 aa 24.3 %
Candida albicans phenylalanine--tRNA ligase Phenylalanyl-tRNA synthetase alpha chain   347 aa 286 aa 29.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis neuropeptide receptor 0.0157 0.2629 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0157 0.2629 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus multilocularis serotonin receptor 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Schistosoma mansoni hypothetical protein 0.0157 0.2629 1
Brugia malayi G-protein coupled receptor 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) neuropeptide F receptor 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0157 0.2629 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0157 0.2629 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0157 0.2629 1
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0088 0.0714 0.1193
Schistosoma mansoni adenoreceptor 0.0157 0.2629 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0157 0.2629 1
Echinococcus granulosus dro:myosuppressin receptor 0.0157 0.2629 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis g protein coupled receptor 0.0157 0.2629 1
Schistosoma mansoni hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0157 0.2629 1
Echinococcus multilocularis nmda type glutamate receptor 0.0083 0.056 0.0489
Schistosoma mansoni amine GPCR 0.0157 0.2629 1
Brugia malayi G protein-coupled receptor 0.0157 0.2629 1
Echinococcus multilocularis neuropeptides capa receptor 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus multilocularis fmrfamide receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus neuropeptides capa receptor 0.0157 0.2629 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0157 0.2629 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis somatostatin receptor 0.0157 0.2629 1
Echinococcus multilocularis neuropeptide Y receptor 0.0157 0.2629 1
Brugia malayi sulfakinin receptor protein 0.0157 0.2629 1
Echinococcus granulosus neuropeptide Y receptor 0.0157 0.2629 1
Schistosoma mansoni opsin-like receptor 0.0157 0.2629 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus sex peptide receptor 0.0157 0.2629 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0157 0.2629 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0157 0.2629 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0157 0.2629 1
Schistosoma mansoni neuropeptide receptor 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0157 0.2629 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0157 0.2629 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0088 0.0714 0.5
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi Dopamine receptor protein 2 0.0157 0.2629 1
Echinococcus multilocularis neuropeptide Y receptor 0.0157 0.2629 1
Brugia malayi neuropeptide F receptor 0.0157 0.2629 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0157 0.2629 1
Brugia malayi Serotonin receptor 0.0157 0.2629 1
Echinococcus multilocularis g protein coupled receptor 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Brugia malayi G-protein coupled receptor 0.0157 0.2629 1
Echinococcus granulosus fmrfamide receptor 0.0157 0.2629 1
Brugia malayi larval opioid receptor 0.0157 0.2629 1
Brugia malayi Melatonin receptor type 1A 0.0157 0.2629 1
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0088 0.0714 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0157 0.2629 1
Brugia malayi GnHR receptor homolog 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Brugia malayi hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Brugia malayi putative neuropeptide receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0157 0.2629 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0714 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus tm gpcr rhodopsin 0.0157 0.2629 1
Echinococcus granulosus hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0157 0.2629 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0714 0.5
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0157 0.2629 1
Schistosoma mansoni histamine h1 receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0157 0.2629 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0157 0.2629 1
Echinococcus granulosus g protein coupled receptor 0.0157 0.2629 1
Brugia malayi ORL1-like opioid receptor 0.0157 0.2629 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0157 0.2629 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0157 0.2629 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0157 0.2629 1
Echinococcus multilocularis nmda type glutamate receptor 0.0106 0.1194 0.3401
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0157 0.2629 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0157 0.2629 1
Schistosoma mansoni myosin xvIII 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni opsin-like receptor 0.0157 0.2629 1
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0088 0.0714 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Schistosoma mansoni biogenic amine receptor 0.0157 0.2629 1
Echinococcus multilocularis serotonin receptor 0.0157 0.2629 1
Echinococcus granulosus somatostatin receptor 0.0157 0.2629 1
Schistosoma mansoni amine GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0157 0.2629 1
Schistosoma mansoni biogenic amine receptor 0.0157 0.2629 1
Schistosoma mansoni neuropeptide receptor 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus neuropeptides capa receptor 0.0157 0.2629 1
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0088 0.0714 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.0422 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0157 0.2629 1
Brugia malayi Dopamine receptor 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Schistosoma mansoni hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus G protein coupled receptor 139 0.0157 0.2629 1
Echinococcus granulosus tm gpcr rhodopsin 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0714 0.5
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus allatostatin A receptor 0.0157 0.2629 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0157 0.2629 1
Echinococcus multilocularis allatostatin A receptor 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Schistosoma mansoni opsin-like receptor 0.0157 0.2629 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0157 0.2629 1
Echinococcus granulosus neuropeptide Y receptor 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus g-protein coupled receptor 0.0157 0.2629 1
Echinococcus multilocularis fmrfamide receptor 0.0157 0.2629 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0157 0.2629 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0157 0.2629 1
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0088 0.0714 0.5
Schistosoma mansoni neuropeptide receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0157 0.2629 1
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.0422 1 0.5
Brugia malayi Serotonin receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0063 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0157 0.2629 1
Echinococcus granulosus neuropeptide receptor 0.0157 0.2629 1
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0088 0.0714 0.1193
Brugia malayi putative neuropeptide receptor NPR1 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0422 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0157 0.2629 1
Echinococcus granulosus neuropeptide receptor A26 0.0157 0.2629 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0157 0.2629 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0157 0.2629 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0157 0.2629 1
Echinococcus multilocularis G protein coupled receptor 139 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0157 0.2629 1
Echinococcus multilocularis sex peptide receptor 0.0157 0.2629 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi neuropeptide F receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) G-protein coupled receptor 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus granulosus neuropeptide receptor 0.0157 0.2629 1
Schistosoma mansoni amine GPCR 0.0157 0.2629 1
Echinococcus granulosus orexin receptor type 2 0.0157 0.2629 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0157 0.2629 1
Echinococcus granulosus g protein coupled receptor 0.0157 0.2629 1
Schistosoma mansoni amine GPCR 0.0157 0.2629 1
Echinococcus granulosus g protein coupled receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni biogenic amine receptor 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis g protein coupled receptor 0.0157 0.2629 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0157 0.2629 1
Echinococcus multilocularis neuropeptide receptor A26 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis neuropeptides capa receptor 0.0157 0.2629 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0157 0.2629 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0157 0.2629 1
Loa Loa (eye worm) TYRA-2 protein 0.0157 0.2629 1
Brugia malayi hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis orexin receptor type 2 0.0157 0.2629 1
Brugia malayi AKH receptor 0.0157 0.2629 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0157 0.2629 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0157 0.2629 1
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0088 0.0714 0.5
Brugia malayi hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0157 0.2629 1
Brugia malayi RE15519p 0.0157 0.2629 1
Schistosoma mansoni amine GPCR 0.0157 0.2629 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0157 0.2629 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0157 0.2629 1
Brugia malayi Dopamine receptor protein 1 0.0157 0.2629 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) neuropeptide F receptor 0.0157 0.2629 1
Echinococcus granulosus neuropeptide s receptor 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Echinococcus granulosus nmda type glutamate receptor 0.0083 0.056 0.0489
Echinococcus granulosus 7tm_1 domain containing protein 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Loa Loa (eye worm) G-protein coupled receptor 0.0157 0.2629 1
Echinococcus multilocularis neuropeptide receptor 0.0157 0.2629 1
Schistosoma mansoni hypothetical protein 0.0157 0.2629 1
Onchocerca volvulus 0.0157 0.2629 0.5
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0088 0.0714 0.5
Echinococcus granulosus serotonin receptor 0.0157 0.2629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Brugia malayi follicle stimulating hormone receptor 0.0157 0.2629 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.2629 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Schistosoma mansoni glutamate receptor NMDA 0.009 0.0768 0.0284
Onchocerca volvulus 0.0157 0.2629 0.5
Echinococcus granulosus nmda type glutamate receptor 0.0106 0.1194 0.3401
Loa Loa (eye worm) hypothetical protein 0.0157 0.2629 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0157 0.2629 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.07 uM Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus ChEMBL. 14980694
IC50 (binding) = 0.07 uM Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus ChEMBL. 14980694
IC50 (binding) = 0.22 uM Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis ChEMBL. 14980694
IC50 (binding) = 0.22 uM Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis ChEMBL. 14980694
IC50 (binding) > 100 uM Inhibitory activity against human phenylalanyl-tRNA synthetase was determined ChEMBL. 14980694
IC50 (binding) > 100 uM Inhibitory activity against human phenylalanyl-tRNA synthetase was determined ChEMBL. 14980694

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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