Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transforming growth factor, beta receptor II (70/80kDa) | Starlite/ChEMBL | References |
Homo sapiens | activin A receptor, type IB | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | TGF-beta receptor type-1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Schistosoma japonicum | ko:K04674 transforming growth factor, beta receptor I, putative | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Echinococcus multilocularis | TGF beta receptor type 1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Schistosoma mansoni | protein kinase | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Brugia malayi | bone morphogenetic protein type 1 receptor | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Echinococcus granulosus | TGF beta receptor type 1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0195 | 0.1024 | 1 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0191 | 0.1 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0532 | 0.3547 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0532 | 0.3547 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0532 | 0.3547 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0532 | 0.3547 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.1393 | 1 | 0.5 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0191 | 0.1 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.1393 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.1393 | 1 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.1393 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.1393 | 1 | 0.5 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0074 | 0.0119 | 0.0023 |
Schistosoma mansoni | protein kinase | 0.0191 | 0.1 | 1 |
Echinococcus multilocularis | activin receptor type | 0.009 | 0.0239 | 0.0324 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0532 | 0.3547 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.1393 | 1 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0532 | 0.3547 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0532 | 0.3547 | 0.5 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0074 | 0.0119 | 0.0023 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0191 | 0.1 | 1 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0195 | 0.1024 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1393 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0074 | 0.0119 | 0.0023 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.1393 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.422 uM | Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | ChEMBL. | 16539403 |
IC50 (functional) | = 0.422 uM | Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | ChEMBL. | 16539403 |
IC50 (functional) | = 0.872 uM | Inhibitory activity against TGFbeta-stimulated proliferation in NIH3T3 cells | ChEMBL. | 16539403 |
IC50 (binding) | = 1.7 uM | Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | ChEMBL. | 16539403 |
IC50 (binding) | = 1.7 uM | Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | ChEMBL. | 16539403 |
IC50 (binding) | = 8.73 uM | Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells | ChEMBL. | 16539403 |
IC50 (binding) | = 8.73 uM | Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells | ChEMBL. | 16539403 |
IC50 (binding) | > 20 uM | Inhibition of MLK7 | ChEMBL. | 16539403 |
IC50 (binding) | > 20 uM | Inhibition of MLK7 | ChEMBL. | 16539403 |
Inhibition (functional) | = 65 % | Inhibition of TGFbeta R1 in human Calu6 cells implanted in nude mouse at 50 mg/kg, po | ChEMBL. | 16539403 |
Inhibition (functional) | = 65 % | Inhibition of TGFbeta R1 in human Calu6 cells implanted in nude mouse at 50 mg/kg, po | ChEMBL. | 16539403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.