Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | squalene epoxidase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0412 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.16 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.16 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0412 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1067 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.16 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0042 | 0.16 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.0293 | 0.0114 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0201 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.0533 | 0.0359 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0201 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0412 | 0.6567 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0412 | 0.1629 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Brugia malayi | polk-prov protein | 0.0031 | 0.1067 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0412 | 0.2609 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0412 | 0.5 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0201 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.0293 | 0.0114 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.0533 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0412 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0412 | 0.2609 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0412 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.16 | 0.1446 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0412 | 0.0236 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0412 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0031 | 0.1067 | 0.0903 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0412 | 0.0236 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.16 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0412 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.16 | 0.1446 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0412 | 0.1629 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0031 | 0.1067 | 0.0903 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.0533 | 0.0359 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.0293 | 0.0114 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0412 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0533 | 0.0359 |
Trypanosoma brucei | unspecified product | 0.0035 | 0.1248 | 0.1087 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0042 | 0.16 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0412 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.0533 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0412 | 0.0236 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.16 | 0.1446 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0035 | 0.1248 | 0.1087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.