Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | caspase 1, apoptosis-related cysteine peptidase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | caspase 8 | caspase 1, apoptosis-related cysteine peptidase | 383 aa | 312 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | C-8 sterol isomerase-like protein | 0.1856 | 0.7543 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0949 | 0.3754 | 0.3754 |
Echinococcus multilocularis | caspase 2 | 0.0071 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0147 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0147 | 0.0407 | 0.0407 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0071 | 0.0089 | 0.0089 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.2445 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0147 | 0.0407 | 0.0407 |
Echinococcus multilocularis | serotonin transporter | 0.0147 | 0.0407 | 0.0407 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0147 | 0.0407 | 0.0407 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0147 | 0.0407 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0147 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0407 | 0.0407 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0147 | 0.0407 | 0.0407 |
Onchocerca volvulus | 0.0147 | 0.0407 | 0.0407 | |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.2445 | 1 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.1856 | 0.7543 | 0.7543 |
Brugia malayi | Cell death protein 3 precursor | 0.0071 | 0.0089 | 0.0089 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0071 | 0.0089 | 0.0089 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.2445 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0089 | 0.0089 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1856 | 0.7543 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0147 | 0.0407 | 0.0407 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1856 | 0.7543 | 0.5 |
Echinococcus granulosus | caspase 2 | 0.0071 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.1856 | 0.7543 | 0.7543 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.2445 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.2445 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 7.1 nM | Reversible inhibition of recombinant human IL-1 beta converting enzyme. | ChEMBL. | No reference |
Ki (binding) | = 7.1 nM | Reversible inhibition of recombinant human IL-1 beta converting enzyme. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.