Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Adrenergic receptor alpha-2 | 450 aa | 473 aa | 24.1 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Adrenergic receptor alpha-2 | 450 aa | 378 aa | 20.9 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 420 aa | 19.8 % | |
Echinococcus granulosus | biogenic amine 5HT receptor | Adrenergic receptor alpha-2 | 450 aa | 423 aa | 31.7 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 467 aa | 25.1 % | |
Echinococcus granulosus | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 476 aa | 21.0 % |
Echinococcus multilocularis | serotonin receptor | Adrenergic receptor alpha-2 | 450 aa | 426 aa | 31.9 % |
Echinococcus multilocularis | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 478 aa | 20.7 % |
Schistosoma mansoni | amine GPCR | Adrenergic receptor alpha-2 | 450 aa | 439 aa | 29.2 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Adrenergic receptor alpha-2 | 450 aa | 433 aa | 27.9 % |
Loa Loa (eye worm) | TYRA-2 protein | Adrenergic receptor alpha-2 | 450 aa | 488 aa | 23.8 % |
Echinococcus multilocularis | neuropeptides capa receptor | Adrenergic receptor alpha-2 | 450 aa | 486 aa | 20.6 % |
Echinococcus multilocularis | fmrfamide receptor | Adrenergic receptor alpha-2 | 450 aa | 366 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | casein kinase I alpha | 0.0122 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.0122 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase i | 0.0122 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, delta isoform, putative | 0.0122 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0122 | 1 | 0.5 |
Plasmodium falciparum | casein kinase 1 | 0.0122 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.0122 | 1 | 1 |
Trypanosoma cruzi | casein kinase, putative | 0.0122 | 1 | 1 |
Trypanosoma brucei | casein kinase I, isoform 2 | 0.0122 | 1 | 0.5 |
Trichomonas vaginalis | CK1 family protein kinase | 0.0122 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I delta | 0.0122 | 1 | 0.5 |
Brugia malayi | casein kinase I | 0.0122 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase I delta | 0.0122 | 1 | 0.5 |
Echinococcus granulosus | casein kinase i | 0.0122 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase I delta | 0.0122 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.0122 | 1 | 1 |
Trypanosoma cruzi | casein kinase, putative | 0.0122 | 1 | 1 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.0122 | 1 | 0.5 |
Trichomonas vaginalis | CK1 family protein kinase | 0.0122 | 1 | 0.5 |
Loa Loa (eye worm) | CK1/CK1/CK1-D protein kinase | 0.0122 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase I alpha | 0.0122 | 1 | 0.5 |
Giardia lamblia | Kinase, CK1 Casein kinase | 0.0122 | 1 | 0.5 |
Onchocerca volvulus | 0.0122 | 1 | 1 | |
Trichomonas vaginalis | CK1 family protein kinase | 0.0122 | 1 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0122 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.0122 | 1 | 0.5 |
Toxoplasma gondii | casein kinase I | 0.0122 | 1 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.0122 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.0122 | 1 | 0.5 |
Leishmania major | casein kinase, putative | 0.0122 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.0122 | 1 | 1 |
Echinococcus multilocularis | casein kinase I alpha | 0.0122 | 1 | 0.5 |
Entamoeba histolytica | casein kinase 1, putative | 0.0122 | 1 | 0.5 |
Plasmodium vivax | casein kinase 1, putative | 0.0122 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I delta | 0.0122 | 1 | 0.5 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.0122 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 5.66 | Antagonistic activity against postsynaptic Alpha-1 adrenergic receptor in isolated rat vas deferens using (-)-phenylephrine as agonist | ChEMBL. | 2886664 |
Kd (functional) | = 6.21 | Antagonistic activity against presynaptic alpha-2 adrenergic receptor in isolated rat vas deferens using xylazine as agonist | ChEMBL. | 2886664 |
pA2 (functional) | = 5.66 | Antagonistic activity against postsynaptic Alpha-1 adrenergic receptor in isolated rat vas deferens using (-)-phenylephrine as agonist | ChEMBL. | 2886664 |
pA2 (functional) | = 6.21 | Antagonistic activity against presynaptic alpha-2 adrenergic receptor in isolated rat vas deferens using xylazine as agonist | ChEMBL. | 2886664 |
Selectivity (binding) | = 3.5 | Selectivity ratio of the compound (Alpha-1 : Alpha-2) | ChEMBL. | 2886664 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.