Detailed information for compound 36062

Basic information

Technical information
  • TDR Targets ID: 36062
  • Name: 6-methyl-2-phenyl-4,5-dihydropyridazin-3-one
  • MW: 188.226 | Formula: C11H12N2O
  • H donors: 0 H acceptors: 1 LogP: 1.01 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCC(=NN1c1ccccc1)C
  • InChi: 1S/C11H12N2O/c1-9-7-8-11(14)13(12-9)10-5-3-2-4-6-10/h2-6H,7-8H2,1H3
  • InChiKey: KQVXOJQOQRTUDA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4578-58-9
  • BTB 06145
  • 6-Methyl-2-phenyl-4,5-dihydro-3(2H)-pyridazinone
  • NSC50989
  • AIDS160534
  • ZINC00091471
  • NSC634580
  • Maybridge1_001393
  • 3(2H)-Pyridazinone, 4,5-dihydro-6-methyl-2-phenyl-
  • N-2-Phenyl-6-methyl-2,3,4,5-tetrahydro-3-pyridazinone
  • 4,5-Dihydro-6-methyl-2-phenylpyridazin-3(2H)-one
  • EINECS 224-962-8
  • AIDS-160534

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0099 0.0807 0.068
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0152 0.19 1
Trichomonas vaginalis thymidylate kinase, putative 0.0152 0.19 0.4069
Loa Loa (eye worm) hypothetical protein 0.0161 0.2068 0.065
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.5113 1
Trypanosoma cruzi ribonuclease H1, putative 0.0066 0.0137 0.0267
Trichomonas vaginalis thymidylate kinase, putative 0.0152 0.19 0.4069
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0099 0.0807 0.1547
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0108 0.0991 0.0866
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0099 0.0807 0.1547
Chlamydia trachomatis thymidylate kinase 0.0152 0.19 0.5
Trypanosoma cruzi ribonuclease H1, putative 0.0066 0.0137 0.0267
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.5113 1
Echinococcus multilocularis thymidylate kinase 0.0152 0.19 0.4069
Echinococcus granulosus thymidylate kinase 0.0152 0.19 0.4069
Plasmodium vivax thymidylate kinase, putative 0.0152 0.19 0.2983
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0278 0.4472 1
Toxoplasma gondii DNA polymerase 0.0278 0.4472 1
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0278 0.4472 1
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.014 0.1638 0.3463
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0099 0.0807 0.1579
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.5113 1
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0099 0.0807 0.1547
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.5113 0.5045
Plasmodium vivax DNA polymerase alpha, putative 0.0129 0.1421 0.1675
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0278 0.4472 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.1773 0.1659
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0099 0.0807 0.1547
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0129 0.1421 0.2963
Trypanosoma brucei unspecified product 0.0079 0.0391 0.0258
Leishmania major thymidylate kinase-like protein 0.0152 0.19 0.3717
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.014 0.1638 0.3463
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0278 0.4472 1
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0161 0.2068 0.4454
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0278 0.4472 1
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.014 0.1638 0.1522
Giardia lamblia DNA polymerase alpha subunit A 0.0085 0.0508 0.0857
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0278 0.4472 1
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0278 0.4472 1
Trypanosoma cruzi thymidylate kinase, putative 0.0152 0.19 0.3717
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0099 0.0807 0.1547
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1773 0.3468
Brugia malayi thymidylate kinase 0.0152 0.19 0.4069
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0278 0.4472 0.4396
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0099 0.0807 0.1579
Trypanosoma cruzi thymidylate kinase, putative 0.0152 0.19 0.3717
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0099 0.0807 0.1547
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0223 0.3342 0.6537
Treponema pallidum thymidylate kinase (tmk) 0.0152 0.19 1
Mycobacterium ulcerans hypothetical protein 0.0163 0.2112 1
Brugia malayi DNA polymerase alpha catalytic subunit 0.0129 0.1421 0.2963
Trypanosoma brucei ingi protein (ORF1) 0.0079 0.0391 0.0258
Brugia malayi DNA polymerase family B containing protein 0.0099 0.0807 0.1547
Onchocerca volvulus Putative thymidylate kinase 0.0152 0.19 0.4069
Toxoplasma gondii thymidylate kinase 0.0152 0.19 0.4069
Trypanosoma brucei RNA helicase, putative 0.0547 1 1
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0108 0.0991 0.1938
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0278 0.4472 0.8746
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0152 0.19 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.2112 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1773 0.3468
Brugia malayi DNA polymerase delta catalytic subunit 0.0278 0.4472 1
Onchocerca volvulus DNA polymerase homolog 0.0099 0.0807 0.1547
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0099 0.0807 0.1579
Trypanosoma brucei thymidylate kinase, putative 0.0152 0.19 0.1788
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0108 0.0991 0.1971
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0099 0.0807 0.1547
Toxoplasma gondii DNA polymerase family B protein 0.0099 0.0807 0.1547
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0099 0.0807 0.1547
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0278 0.4472 1
Trypanosoma brucei ingi protein (ORF1) 0.0079 0.0391 0.0258
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0278 0.4472 0.4396
Schistosoma mansoni hypothetical protein 0.0152 0.19 0.1788
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0108 0.0991 0.1938
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0278 0.4472 0.8746
Leishmania major ribonuclease H1, putative 0.0066 0.0137 0.0267
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0391 0.0258
Trypanosoma brucei thymidylate kinase, putative 0.0152 0.19 0.1788
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0278 0.4472 1
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0099 0.0807 0.1547
Schistosoma mansoni thymidylate kinase 0.0152 0.19 0.1788
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0099 0.0807 0.068
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0099 0.0807 0.068
Trichomonas vaginalis DNA polymerase II, putative 0.0108 0.0991 0.1971
Giardia lamblia CDC8 0.0152 0.19 0.4069
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0099 0.0807 0.068
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0079 0.0391 0.0258
Schistosoma mansoni thymidylate kinase 0.0152 0.19 0.1788

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) NA 0 In vitro inhibition of 5-Lipoxygenase; Inactive. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.