Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.0181 | 0.1403 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0083 | 0.0578 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0061 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0061 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0251 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0083 | 0.0648 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0078 | 0.2671 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0023 | 0.0061 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Onchocerca volvulus | 0.0081 | 0.0251 | 1 | |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0008 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0083 | 0.0648 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.0061 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0083 | 0.0578 |
Trypanosoma brucei | lanosterol synthase | 0.3081 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.0251 | 0.1891 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0015 | 0.0044 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0061 | 0.5 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0023 | 0.0061 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0015 | 0.0044 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0078 | 0.0608 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.2048 | 0.6644 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0078 | 0.2682 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.0251 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.3081 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0061 | 0.5 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0061 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.001 | 0.0074 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0061 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.3081 | 1 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.0251 | 0.1891 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Echinococcus granulosus | dnaJ subfamily B | 0.04 | 0.1288 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.0251 | 0.1952 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.04 | 0.1288 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.016 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Echinococcus multilocularis | dnaJ subfamily B | 0.04 | 0.1288 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.1 ug ml-1 | Minimum inhibitory concentration against Trichophyton asteroides | ChEMBL. | 3302257 |
MIC (functional) | = 0.8 ug ml-1 | Minimum inhibitory concentration against Trichophyton mentagrophytes IFO 5810 | ChEMBL. | 3302257 |
MIC (functional) | = 0.8 ug ml-1 | Minimum inhibitory concentration against Trichophyton rubrum IFO 5467 | ChEMBL. | 3302257 |
MIC (functional) | = 1.6 ug ml-1 | Minimum inhibitory concentration against Trichophyton mentagrophytes IFO 5809 | ChEMBL. | 3302257 |
MIC (functional) | = 1.6 ug ml-1 | Minimum inhibitory concentration against Trichophyton rubrum IFO 5807 | ChEMBL. | 3302257 |
MIC (functional) | = 3.1 ug ml-1 | Minimum inhibitory concentration (MIC) against Aspergillus fumigatus | ChEMBL. | 3302257 |
MIC (functional) | = 6.2 ug ml-1 | Minimum inhibitory concentration (MIC) against Candida albicans | ChEMBL. | 3302257 |
MIC (functional) | = 6.2 ug ml-1 | Minimum inhibitory concentration (MIC) against Candida albicans | ChEMBL. | 3302257 |
MIC (functional) | = 12.5 ug ml-1 | Minimum inhibitory concentration against Candida albicans IFO 1060 | ChEMBL. | 3302257 |
MIC (functional) | = 12.5 ug ml-1 | Minimum inhibitory concentration against Candida albicans IFO 1388 | ChEMBL. | 3302257 |
MIC (functional) | = 12.5 ug ml-1 | Minimum inhibitory concentration against Candida albicans IFO 1060 | ChEMBL. | 3302257 |
MIC (functional) | = 12.5 ug ml-1 | Minimum inhibitory concentration against Candida albicans IFO 1388 | ChEMBL. | 3302257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.