Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus subsp. aureus Mu50 | Peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trichomonas vaginalis | abca6, putative | Peptide deformylase | 183 aa | 162 aa | 25.3 % |
Trypanosoma cruzi | hypothetical protein | Peptide deformylase | 183 aa | 155 aa | 22.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 0.0452 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 0.0452 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 0.0452 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 0.0452 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 0.0452 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 0.0452 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 0.0452 | 0.5 |
Trypanosoma brucei | adenosine transporter, putative | 0.3921 | 1 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0 | 0.5 |
Chlamydia trachomatis | peptide deformylase | 0.0279 | 0.0452 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.46 uM | Inhibition of Peptidyl deformylase (PDF) | ChEMBL. | 11378353 |
IC50 (binding) | = 0.46 uM | Inhibition of Peptidyl deformylase (PDF) | ChEMBL. | 11378353 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Staphylococcus aureus (SAUR) 9218 | ChEMBL. | 11378353 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Staphylococcus epidermidis (SEPI) 12084 | ChEMBL. | 11378353 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae (SPNE) 9912 | ChEMBL. | 11378353 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against E. coli (ECOL) 6674 | ChEMBL. | 11378353 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against E. coli (ECOL) 6674 | ChEMBL. | 11378353 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.