Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0078 | 0.2682 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.001 | 0.0074 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0061 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0023 | 0.0061 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.016 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.3081 | 1 | 0.5 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.0061 | 0.5 |
Echinococcus granulosus | dnaJ subfamily B | 0.04 | 0.1288 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0078 | 0.2671 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.0251 | 1 |
Trypanosoma brucei | lanosterol synthase | 0.3081 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0015 | 0.0044 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Echinococcus multilocularis | dnaJ subfamily B | 0.04 | 0.1288 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.3081 | 1 | 0.5 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.0251 | 0.1891 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.2048 | 0.6644 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0078 | 0.0608 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.0251 | 0.1891 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Onchocerca volvulus | 0.0081 | 0.0251 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0061 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0008 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0083 | 0.0578 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0083 | 0.0648 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0023 | 0.0061 | 0.5 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.0251 | 0.1952 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0083 | 0.0578 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0061 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0083 | 0.0648 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0061 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0251 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0015 | 0.0044 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.0181 | 0.1403 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0061 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0008 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.04 | 0.1288 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0008 | 0.5 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0061 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.1 ug ml-1 | Minimum inhibitory concentration against Trichophyton asteroides | ChEMBL. | 3302257 |
MIC (functional) | = 0.8 ug ml-1 | Minimum inhibitory concentration against Trichophyton mentagrophytes IFO 5809 | ChEMBL. | 3302257 |
MIC (functional) | = 0.8 ug ml-1 | Minimum inhibitory concentration against Trichophyton mentagrophytes IFO 5810 | ChEMBL. | 3302257 |
MIC (functional) | = 0.8 ug ml-1 | Minimum inhibitory concentration against Trichophyton rubrum IFO 5467 | ChEMBL. | 3302257 |
MIC (functional) | = 0.8 ug ml-1 | Minimum inhibitory concentration against Trichophyton rubrum IFO 5807 | ChEMBL. | 3302257 |
MIC (functional) | = 3.1 ug ml-1 | Minimum inhibitory concentration (MIC) against Aspergillus fumigatus | ChEMBL. | 3302257 |
MIC (functional) | = 6.2 ug ml-1 | Minimum inhibitory concentration (MIC) against Candida albicans | ChEMBL. | 3302257 |
MIC (functional) | = 12.5 ug ml-1 | Minimum inhibitory concentration against Candida albicans IFO 1060 | ChEMBL. | 3302257 |
MIC (functional) | = 12.5 ug ml-1 | Minimum inhibitory concentration against Candida albicans IFO 1388 | ChEMBL. | 3302257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.