Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | 0.5324 | 0.4605 | 0.474 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 1.1522 | 1 | 1 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0097 | 0.0057 | 0.0055 |
Loa Loa (eye worm) | thymidylate synthase | 1.119 | 0.9711 | 1 |
Loa Loa (eye worm) | FolC protein | 0.0097 | 0.0057 | 0.0058 |
Brugia malayi | Dihydrofolate reductase | 0.0868 | 0.0728 | 0.0749 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0868 | 0.0728 | 0.0749 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0164 | 0.0115 | 1 |
Plasmodium vivax | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0097 | 0.0057 | 0.0057 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0868 | 0.0728 | 0.0695 |
Trichomonas vaginalis | conserved hypothetical protein | 0.5324 | 0.4605 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0868 | 0.0728 | 0.0695 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0097 | 0.0057 | 0.0055 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | folylpolyglutamate synthase | 0.0097 | 0.0057 | 0.0058 |
Entamoeba histolytica | kinesin, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.5324 | 0.4605 | 0.4574 |
Brugia malayi | thymidylate synthase | 1.119 | 0.9711 | 1 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0097 | 0.0057 | 0.0055 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 1.1522 | 1 | 1 |
Plasmodium falciparum | dihydrofolate synthase/folylpolyglutamate synthase | 0.0097 | 0.0057 | 0.0057 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0164 | 0.0115 | 0.0115 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 1.1522 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0868 | 0.0728 | 0.0746 |
Brugia malayi | dihydrofolate reductase family protein | 0.0868 | 0.0728 | 0.0749 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0868 | 0.0728 | 0.0746 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 1.119 | 0.9711 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0868 | 0.0728 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 1.1522 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 1.119 | 0.9711 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0164 | 0.0115 | 0.0115 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0097 | 0.0057 | 0.0055 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 1.119 | 0.9711 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0868 | 0.0728 | 0.0746 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0097 | 0.0057 | 0.5 |
Echinococcus granulosus | kinesin family 1 | 0.0247 | 0.0187 | 0.0135 |
Mycobacterium ulcerans | thymidylate synthase | 1.119 | 0.9711 | 1 |
Toxoplasma gondii | bifunctional protein FolC subfamily protein | 0.0097 | 0.0057 | 0.0057 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.0159 | 0.0164 |
Onchocerca volvulus | 1.119 | 0.9711 | 1 | |
Brugia malayi | hypothetical protein | 0.5324 | 0.4605 | 0.4742 |
Echinococcus multilocularis | thymidylate synthase | 1.119 | 0.9711 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 0.0187 | 0.0135 |
Brugia malayi | FolC bifunctional protein | 0.0097 | 0.0057 | 0.0058 |
Schistosoma mansoni | dihydrofolate reductase | 0.0868 | 0.0728 | 0.0749 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 1.1522 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 1.119 | 0.9711 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.86 uM | Antiproliferative activity against human A2780 cells after 72 hrs | ChEMBL. | 16730979 |
IC50 (functional) | = 2.86 uM | Antiproliferative activity against human A2780 cells after 72 hrs | ChEMBL. | 16730979 |
IC50 (binding) | = 6.88 uM | Inhibition of human Eg5 ATPase activity | ChEMBL. | 16730979 |
IC50 (binding) | = 6.88 uM | Inhibition of human Eg5 ATPase activity | ChEMBL. | 16730979 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 16730979 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.