Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin alpha ps | 0.0496 | 0.0854 | 0.154 |
Schistosoma mansoni | integrin alpha-ps | 0.0538 | 0.0982 | 0.1567 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.0854 | 0.0435 |
Echinococcus granulosus | integrin alpha ps | 0.1034 | 0.2463 | 0.5119 |
Echinococcus multilocularis | integrin alpha ps | 0.1034 | 0.2463 | 0.5119 |
Loa Loa (eye worm) | hypothetical protein | 0.1811 | 0.4785 | 0.4546 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.2307 | 0.6267 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.1034 | 0.2463 | 0.5119 |
Loa Loa (eye worm) | hypothetical protein | 0.1745 | 0.4587 | 0.434 |
Schistosoma mansoni | integrin alpha | 0.2307 | 0.6267 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.1034 | 0.2463 | 0.3931 |
Echinococcus granulosus | integrin alpha 3 | 0.1768 | 0.4658 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1273 | 0.3176 | 0.2864 |
Schistosoma mansoni | hypothetical protein | 0.0496 | 0.0854 | 0.1363 |
Echinococcus multilocularis | integrin alpha 3 | 0.1768 | 0.4658 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0496 | 0.0854 | 0.154 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.0982 | 0.0569 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.1745 | 0.4587 | 0.7119 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED20 (functional) | > 1000 ug kg-1 | Concentration required to reduce mean arterial blood pressure in rat after intravenous administration. | ChEMBL. | 7837224 |
ED50 (functional) | = 5.1 ug kg-1 | Inhibition of vasopressin-induced ECG changes in rat | ChEMBL. | 7837224 |
ED50 (functional) | = 13 ug kg-1 | Inhibition of methacholine-induced ECG changes in the anesthetized rat after intravenous administration. | ChEMBL. | 7837224 |
ED50 (functional) | = 100 ug kg-1 | Inhibition of methacholine-induced ECG changes in the anesthetized rat after oral administration. | ChEMBL. | 7837224 |
IC50 (functional) | = 0.23 uM | Vasorelaxation activity in the isolated endothelium-denuded rabbit aorta | ChEMBL. | 7837224 |
logP (ADMET) | = 1.83 | Partition coefficient (logP) | ChEMBL. | 7837224 |
Selectivity index (functional) | = 421 | Selectivity index of the compound as the ratio of doses requires to induce a reduction in MABP and that required to prevent ECG changes. | ChEMBL. | 7837224 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.