Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0065 | 0.0404 | 0.0337 |
Echinococcus granulosus | expressed protein | 0.0438 | 0.4443 | 1 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0226 | 0.2277 |
Echinococcus granulosus | snurportin 1 | 0.0361 | 0.3612 | 0.81 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0226 | 0.0443 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0069 | 0.0451 | 0.4219 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0336 | 0.0753 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0027 | 0.0000033294 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0136 | 0.0188 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0136 | 0.0966 |
Echinococcus granulosus | caspase 2 | 0.0069 | 0.0451 | 0.0873 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0759 | 0.1947 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0098 | 0.0759 | 0.0694 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0336 | 0.387 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0361 | 0.3612 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0034 | 0.0069 | 0.0208 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0335 | 0.3327 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0034 | 0.0069 | 0.0208 |
Brugia malayi | RNA, U transporter 1 | 0.0096 | 0.0744 | 0.9789 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0226 | 0.0443 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0098 | 0.0759 | 0.1947 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0199 | 0.1855 | 0.4083 |
Schistosoma mansoni | hypothetical protein | 0.0199 | 0.1855 | 0.504 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0335 | 0.3327 | 1 |
Echinococcus multilocularis | geminin | 0.0199 | 0.1855 | 0.1798 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0000033294 | 1 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0048 | 0.0226 | 0.0359 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0069 | 0.0451 | 0.1077 |
Treponema pallidum | hypothetical protein | 0.0335 | 0.3327 | 1 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0027 | 0.0000033294 | 1 |
Echinococcus multilocularis | expressed protein | 0.0438 | 0.4443 | 0.4404 |
Schistosoma mansoni | hypothetical protein | 0.0361 | 0.3612 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0361 | 0.3612 | 0.3567 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0336 | 0.387 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0335 | 0.3327 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0027 | 0 | 0.5 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0034 | 0.0069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0336 | 0.0753 |
Trichomonas vaginalis | importin beta-1, putative | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0065 | 0.0404 | 0.0945 |
Onchocerca volvulus | 0.0098 | 0.0759 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0451 | 0.1077 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0335 | 0.3327 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0199 | 0.1855 | 0.504 |
Echinococcus multilocularis | caspase 2 | 0.0069 | 0.0451 | 0.0384 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0335 | 0.3327 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0069 | 0.0451 | 0.5535 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0136 | 0.0188 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0098 | 0.0759 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0027 | 0.0000033294 | 0.5 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0098 | 0.0759 | 0.1577 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0048 | 0.0226 | 0.0158 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0065 | 0.0404 | 0.0766 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0069 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 65 nM | Induction of apoptosis in human DLD1 cells assessed as activation of caspases by HTS assay | ChEMBL. | 16784854 |
EC50 (functional) | = 65 nM | Induction of apoptosis in human DLD1 cells assessed as activation of caspases by HTS assay | ChEMBL. | 16784854 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 16784854 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.