TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 390.521 | Formula: C24H30N4O
H donors: 1 H acceptors: 1 LogP: 2.93 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN1C(=Nc2c(C1CC(=O)NCc1ccccc1)cccc2)N1CCCCC1
InChi: 1S/C24H30N4O/c1-2-28-22(17-23(29)25-18-19-11-5-3-6-12-19)20-13-7-8-14-21(20)26-24(28)27-15-9-4-10-16-27/h3,5-8,11-14,22H,2,4,9-10,15-18H2,1H3,(H,25,29)
InChiKey: OTPISXIISBCQOC-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calcium channel, voltage-dependent, T type, alpha 1G subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129328	All targets in OG5_129328
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	Get druggable targets OG5_129328	All targets in OG5_129328
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_129328	All targets in OG5_129328

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.011	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.011	0.011
Echinococcus multilocularis	cathepsin L cysteine protease	0.0053	0.086	0.086
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0034	0.011	0.011
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0034	0.011	0.011
Brugia malayi	Cathepsin L-like precursor	0.0053	0.086	0.086
Entamoeba histolytica	cysteine protease, putative	0.0053	0.086	1
Echinococcus multilocularis	cathepsin b	0.0282	1	1
Brugia malayi	G protein-coupled receptor	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0185	0.6144	0.6144
Brugia malayi	neuropeptide F receptor	0.0034	0.011	0.011
Brugia malayi	Cathepsin L-like precursor	0.0038	0.0274	0.0274
Onchocerca volvulus		0.0053	0.086	0.1243
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0034	0.011	0.011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.011	0.011
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0034	0.011	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Schistosoma mansoni	amine GPCR	0.0034	0.011	0.011
Brugia malayi	hypothetical protein	0.0034	0.011	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.086	0.3201
Echinococcus multilocularis	fmrfamide receptor	0.0034	0.011	0.011
Brugia malayi	Serotonin receptor	0.0034	0.011	0.011
Echinococcus granulosus	neuropeptide Y receptor	0.0034	0.011	0.011
Schistosoma mansoni	neuropeptide receptor	0.0034	0.011	0.011
Schistosoma mansoni	amine GPCR	0.0034	0.011	0.011
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0053	0.086	0.0759
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0034	0.011	0.011
Echinococcus multilocularis	sex peptide receptor	0.0034	0.011	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.086	0.3201
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0185	0.6144	0.6144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Schistosoma mansoni	opsin-like receptor	0.0034	0.011	0.011
Echinococcus granulosus	fmrfamide receptor	0.0034	0.011	0.011
Echinococcus multilocularis	g-protein coupled receptor	0.0034	0.011	0.011
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0214	0.7312	0.7312
Brugia malayi	Cathepsin L-like precursor	0.0053	0.086	0.086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.011	0.011
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.086	1
Echinococcus granulosus	neuropeptide Y receptor	0.0034	0.011	0.011
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0282	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.086	0.1215
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.086	0.3201
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0053	0.086	0.086
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.011	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.086	0.3201
Brugia malayi	follicle stimulating hormone receptor	0.0034	0.011	0.011
Loa Loa (eye worm)	cathepsin B	0.0098	0.2688	0.2606
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0034	0.011	0.011
Schistosoma mansoni	cathepsin F (C01 family)	0.0053	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Schistosoma mansoni	biogenic amine receptor	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.086	0.1215
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0185	0.6144	0.6101
Schistosoma mansoni	hypothetical protein	0.0034	0.011	0.011
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0034	0.011	0.011
Echinococcus multilocularis	allatostatin A receptor	0.0034	0.011	0.011
Brugia malayi	GnHR receptor homolog	0.0034	0.011	0.011
Brugia malayi	neuropeptide F receptor	0.0034	0.011	0.011
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0034	0.011	0.011
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.086	0.1243
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0034	0.011	0.011
Echinococcus multilocularis	G protein coupled receptor 139	0.0034	0.011	0.011
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0282	1	1
Schistosoma mansoni	adenoreceptor	0.0034	0.011	0.011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.011	0.011
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0034	0.011	0.011
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0034	0.011	0.011
Echinococcus multilocularis	cysteine protease	0.0053	0.086	0.086
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0034	0.011	0.011
Echinococcus granulosus	somatostatin receptor	0.0034	0.011	0.011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.011	0.011
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0034	0.011	0.011
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.011	0.011
Brugia malayi	hypothetical protein	0.0034	0.011	0.011
Echinococcus granulosus	cathepsin b	0.0282	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.086	0.086
Schistosoma mansoni	myosin xvIII	0.0034	0.011	0.011
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0034	0.011	0.011
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0282	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0053	0.086	0.086
Brugia malayi	G-protein coupled receptor	0.0034	0.011	0.011
Brugia malayi	hypothetical protein	0.0034	0.011	0.011
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0034	0.011	0.011
Brugia malayi	larval opioid receptor	0.0034	0.011	0.011
Onchocerca volvulus		0.0053	0.086	0.1243
Giardia lamblia	Cathepsin B precursor	0.0098	0.2688	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0034	0.011	0.011
Onchocerca volvulus		0.0038	0.0274	0.0271
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0034	0.011	0.011
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.011	0.011
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0034	0.011	0.011
Entamoeba histolytica	cysteine proteinase, putative	0.0038	0.0274	0.3182
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0034	0.011	0.011
Echinococcus granulosus	g protein coupled receptor	0.0034	0.011	0.011
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.011	0.011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.011	0.011
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0053	0.086	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.086	0.3201
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.086	0.1243
Echinococcus multilocularis	cathepsin L cysteine protease	0.0053	0.086	0.086
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0185	0.6144	0.6144
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.086	0.1215
Brugia malayi	Cathepsin L-like precursor	0.0053	0.086	0.086
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.011	0.011
Echinococcus multilocularis	neuropeptide receptor	0.0034	0.011	0.011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.011	0.011
Schistosoma mansoni	amine GPCR	0.0034	0.011	0.011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.011	0.011
Brugia malayi	Dopamine receptor	0.0034	0.011	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.086	0.1215
Echinococcus multilocularis	somatostatin receptor	0.0034	0.011	0.011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.011	0.011
Loa Loa (eye worm)	ctsf protein	0.0053	0.086	0.0759
Echinococcus granulosus	cathepsin l1	0.0053	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.086	0.3201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.011	0.011
Onchocerca volvulus		0.0053	0.086	0.1243
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.011	0.011
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.086	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0274	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0274	0.0166
Echinococcus granulosus	neuropeptide receptor	0.0034	0.011	0.011
Schistosoma mansoni	hypothetical protein	0.0034	0.011	0.011
Plasmodium vivax	vivapain-2	0.0053	0.086	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.086	0.1215
Schistosoma mansoni	hypothetical protein	0.0034	0.011	0.011
Echinococcus granulosus	biogenic amine 5HT receptor	0.0034	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0053	0.086	0.0759
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0034	0.011	0.011
Echinococcus granulosus	neuropeptide FF receptor 2	0.0034	0.011	0.011
Echinococcus granulosus	neuropeptides capa receptor	0.0034	0.011	0.011
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0098	0.2688	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.011	0.011
Brugia malayi	Melatonin receptor type 1A	0.0034	0.011	0.011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.011	0.011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.011	0.011
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0098	0.2688	0.2688
Schistosoma mansoni	opsin-like receptor	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Echinococcus multilocularis	cysteine protease	0.0053	0.086	0.086
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0185	0.6144	0.6101
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0034	0.011	0.011
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0034	0.011	0.011
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.0274	0.0387
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.011	0.011
Schistosoma mansoni	neuropeptide receptor	0.0034	0.011	0.011
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0034	0.011	0.011
Brugia malayi	G protein-coupled receptor F59B2.13	0.0034	0.011	0.011
Brugia malayi	G-protein coupled receptor	0.0034	0.011	0.011
Brugia malayi	sulfakinin receptor protein	0.0034	0.011	0.011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.011	0.011
Brugia malayi	hypothetical protein	0.0034	0.011	0.011
Echinococcus granulosus	neuropeptide receptor A26	0.0034	0.011	0.011
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0282	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0034	0.011	0.011
Schistosoma mansoni	amine GPCR	0.0034	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0282	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.086	0.0759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0053	0.086	0.1215
Echinococcus multilocularis	orexin receptor type 2	0.0034	0.011	0.011
Echinococcus multilocularis	neuropeptide receptor A26	0.0034	0.011	0.011
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.011	0.011
Onchocerca volvulus		0.0053	0.086	0.1243
Schistosoma mansoni	opsin-like receptor	0.0034	0.011	0.011
Loa Loa (eye worm)	cysteine protease	0.0053	0.086	0.0759
Brugia malayi	Dopamine receptor protein 2	0.0034	0.011	0.011
Brugia malayi	RE15519p	0.0034	0.011	0.011
Brugia malayi	putative neuropeptide receptor	0.0034	0.011	0.011
Echinococcus granulosus	hypothetical protein	0.0034	0.011	0.011
Echinococcus granulosus	g-protein coupled receptor	0.0034	0.011	0.011
Giardia lamblia	Cathepsin B precursor	0.0098	0.2688	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0034	0.011	0.011
Schistosoma mansoni	cathepsin F (C01 family)	0.0053	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.086	0.1215
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.086	0.3201
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.086	0.086
Loa Loa (eye worm)	hypothetical protein	0.0214	0.7312	0.7282
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0098	0.2688	0.2688
Schistosoma mansoni	neuropeptide receptor	0.0034	0.011	0.011
Brugia malayi	Cathepsin L-like precursor	0.0038	0.0274	0.0274
Brugia malayi	Dopamine receptor protein 1	0.0034	0.011	0.011
Echinococcus granulosus	cathepsin l1	0.0038	0.0274	0.0274
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.086	0.1215
Brugia malayi	ORL1-like opioid receptor	0.0034	0.011	0.011
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0034	0.011	0.011
Brugia malayi	hypothetical protein	0.0034	0.011	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.7078	1
Echinococcus multilocularis	neuropeptide s receptor	0.0034	0.011	0.011
Echinococcus multilocularis	neuropeptide receptor	0.0034	0.011	0.011
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.011	0.011
Echinococcus granulosus	neuropeptides capa receptor	0.0034	0.011	0.011
Echinococcus multilocularis	fmrfamide receptor	0.0034	0.011	0.011
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.011	0.011
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0038	0.0274	0.0274
Echinococcus granulosus	allatostatin A receptor	0.0034	0.011	0.011
Brugia malayi	hypothetical protein	0.0034	0.011	0.011
Echinococcus multilocularis	neuropeptide Y receptor	0.0034	0.011	0.011
Schistosoma mansoni	biogenic amine receptor	0.0034	0.011	0.011
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0034	0.011	0.011
Echinococcus granulosus	neuropeptide receptor	0.0034	0.011	0.011
Echinococcus granulosus	7tm_1 domain containing protein	0.0034	0.011	0.011
Echinococcus multilocularis	neuropeptides capa receptor	0.0034	0.011	0.011
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0034	0.011	0.011
Brugia malayi	putative neuropeptide receptor NPR1	0.0034	0.011	0.011
Echinococcus multilocularis	dro:myosuppressin receptor	0.0034	0.011	0.011
Schistosoma mansoni	biogenic amine receptor	0.0034	0.011	0.011
Echinococcus granulosus	orexin receptor type 2	0.0034	0.011	0.011
Brugia malayi	hypothetical protein	0.0034	0.011	0.011
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.086	1
Echinococcus granulosus	neuropeptide s receptor	0.0034	0.011	0.011
Onchocerca volvulus	Cathepsin F homolog	0.0053	0.086	0.1243
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Brugia malayi	Cathepsin L-like precursor	0.0053	0.086	0.086
Echinococcus multilocularis	neuropeptide Y receptor	0.0034	0.011	0.011
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.011	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.086	0.3201
Plasmodium vivax	vivapain-2	0.0053	0.086	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0034	0.011	0.011
Echinococcus granulosus	cathepsin b	0.0282	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0034	0.011	0.011
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0034	0.011	0.011
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0034	0.011	0.011
Onchocerca volvulus		0.0053	0.086	0.1243
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0098	0.2688	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0053	0.086	0.1215
Echinococcus granulosus	g protein coupled receptor	0.0034	0.011	0.011
Brugia malayi	Cathepsin L-like precursor	0.0053	0.086	0.086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.011	0.011
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.011	0.011
Schistosoma mansoni	hypothetical protein	0.0034	0.011	0.011
Echinococcus multilocularis	serotonin receptor	0.0034	0.011	0.011
Schistosoma mansoni	histamine h1 receptor	0.0034	0.011	0.011
Brugia malayi	cathepsin L-like precursor	0.0038	0.0274	0.0274
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0034	0.011	0.011
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0185	0.6144	0.6144
Loa Loa (eye worm)	fibroinase	0.0053	0.086	0.0759
Echinococcus granulosus	serotonin receptor	0.0034	0.011	0.011
Echinococcus multilocularis	neuropeptides capa receptor	0.0034	0.011	0.011
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.086	0.086
Schistosoma mansoni	amine GPCR	0.0034	0.011	0.011
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0034	0.011	0.011
Brugia malayi	Serotonin receptor	0.0034	0.011	0.011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.086	0.1215
Schistosoma mansoni	neuropeptide F-like receptor	0.0034	0.011	0.011
Toxoplasma gondii	cathepsin B	0.0098	0.2688	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0038	0.0274	0.0274
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0034	0.011	0.011
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0034	0.011	0.011
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0034	0.011	0.011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.011	0.011
Echinococcus granulosus	g protein coupled receptor	0.0034	0.011	0.011
Onchocerca volvulus		0.0053	0.086	0.1243
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.011	0.011
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0053	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0274	0.0166
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.086	0.086
Brugia malayi	hypothetical protein	0.0034	0.011	0.011
Echinococcus multilocularis	serotonin receptor	0.0034	0.011	0.011
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0034	0.011	0.011
Onchocerca volvulus		0.0053	0.086	0.1243
Brugia malayi	hypothetical protein	0.0034	0.011	0.011
Trypanosoma cruzi	cruzipain precursor, putative	0.0053	0.086	0.086
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0053	0.086	0.086
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0053	0.086	1
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0185	0.6144	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.086	0.1215
Brugia malayi	AKH receptor	0.0034	0.011	0.011
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0053	0.086	0.086
Brugia malayi	Cathepsin L-like precursor	0.0053	0.086	0.086
Giardia lamblia	Cathepsin B precursor	0.0098	0.2688	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0034	0.011	0.011
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.0274	0.0387
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0282	1	1
Echinococcus multilocularis	cathepsin b	0.0282	1	1
Echinococcus granulosus	sex peptide receptor	0.0034	0.011	0.011
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0098	0.2688	0.3797
Schistosoma mansoni	neuropeptide receptor	0.0034	0.011	0.011
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0034	0.011	0.011
Brugia malayi	hypothetical protein	0.0034	0.011	0.011
Echinococcus granulosus	G protein coupled receptor 139	0.0034	0.011	0.011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.011	0.011
Schistosoma mansoni	cathepsin F (C01 family)	0.0038	0.0274	0.0274
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0034	0.011	0.011
Schistosoma mansoni	serine/threonine protein kinase	0.0185	0.6144	0.6144

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Cytotoxicity against HEK293 cells at 100 uM	ChEMBL.	16876410
GI50 (functional)	= 42.48 uM	Inhibition of human SK-MEL-2 cell growth by SRB assay	ChEMBL.	16876410
GI50 (functional)	= 42.48 uM	Inhibition of human SK-MEL-2 cell growth by SRB assay	ChEMBL.	16876410
GI50 (functional)	= 74.16 uM	Inhibition of human HCT15 cell growth by SRB assay	ChEMBL.	16876410
GI50 (functional)	= 74.16 uM	Inhibition of human HCT15 cell growth by SRB assay	ChEMBL.	16876410
GI50 (functional)	= 77.84 uM	Inhibition of human SKOV3 cell growth by SRB assay	ChEMBL.	16876410
GI50 (functional)	= 77.84 uM	Inhibition of human SKOV3 cell growth by SRB assay	ChEMBL.	16876410
GI50 (functional)	= 95.1 uM	Inhibition of human A549 cell growth by SRB assay	ChEMBL.	16876410
GI50 (functional)	= 95.1 uM	Inhibition of human A549 cell growth by SRB assay	ChEMBL.	16876410
GI50 (functional)	= 108.14 uM	Inhibition of human KB cell growth by SRB assay	ChEMBL.	16876410
GI50 (functional)	= 108.14 uM	Inhibition of human KB cell growth by SRB assay	ChEMBL.	16876410
IC50 (binding)	= 5.339	Inhibition of human T-type calcium channel alpha1G in HEK293 cells	ChEMBL.	19951839
Inhibition (binding)	= 9.3 %	Inhibition of N type calcium channel subunit alpha1B at 10 uM in HEK293 cells	ChEMBL.	16876410
Inhibition (binding)	= 9.3 %	Inhibition of N type calcium channel subunit alpha1B at 10 uM in HEK293 cells	ChEMBL.	16876410
Inhibition (binding)	= 59.3 %	Inhibition of T type calcium channel subunit alpha1G at 10 uM in HEK293 cells	ChEMBL.	16876410
Inhibition (binding)	= 59.3 %	Inhibition of T type calcium channel subunit alpha1G at 10 uM in HEK293 cells	ChEMBL.	16876410

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL384090

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 371931