Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Adenylate and Guanylate cyclase catalytic domain containing protein | 0.0161 | 0.7075 | 0.7075 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0099 | 0.0099 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0133 | 0.5369 | 1 |
Schistosoma mansoni | jun-related protein | 0.0068 | 0.1252 | 0.1769 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.0691 | 0.0691 |
Schistosoma mansoni | soluble guanylate cyclase gcy | 0.0141 | 0.5868 | 0.8293 |
Onchocerca volvulus | 0.0161 | 0.7075 | 0.6711 | |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.7075 | 0.7075 |
Schistosoma mansoni | soluble guanylate cyclase gcy | 0.0161 | 0.7075 | 1 |
Brugia malayi | hypothetical protein | 0.0066 | 0.1107 | 0.1107 |
Schistosoma mansoni | soluble guanylate cyclase gcy | 0.0141 | 0.5868 | 0.8293 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0099 | 0.0099 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0691 | 0.0977 |
Loa Loa (eye worm) | carboxylesterase | 0.0133 | 0.5369 | 0.5369 |
Brugia malayi | bZIP transcription factor family protein | 0.0084 | 0.2237 | 0.2237 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.5396 | 0.7627 |
Echinococcus granulosus | acetylcholinesterase | 0.0133 | 0.5369 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0118 | 0.4428 | 0.8247 |
Schistosoma mansoni | soluble guanylate cyclase gcy | 0.0141 | 0.5868 | 0.8293 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0118 | 0.4428 | 0.8247 |
Loa Loa (eye worm) | guanylyl cyclase/natriuretic peptide receptor | 0.0161 | 0.7075 | 0.7075 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0691 | 0.0977 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0691 | 0.0691 |
Schistosoma mansoni | soluble guanylyl cyclase beta-3 | 0.0134 | 0.5396 | 0.7627 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0059 | 0.0691 | 0.1288 |
Echinococcus granulosus | jun protein | 0.0084 | 0.2237 | 0.4167 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0084 | 0.2237 | 0.4167 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.5369 | 0.5369 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2093 | 0.2093 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.5369 | 0.5369 |
Echinococcus granulosus | acetylcholinesterase | 0.0133 | 0.5369 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0099 | 0.0099 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0059 | 0.0691 | 0.1288 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133 | 0.5369 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0133 | 0.5369 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0133 | 0.5369 | 0.5369 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0059 | 0.0691 | 0.0977 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.5369 | 0.5369 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0059 | 0.0691 | 0.1288 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1252 | 0.1769 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.0691 | 0.0691 |
Schistosoma mansoni | lipoxygenase | 0.0118 | 0.4428 | 0.6259 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0099 | 0.0099 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0059 | 0.0691 | 0.1288 |
Echinococcus multilocularis | jun protein | 0.0084 | 0.2237 | 0.4167 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0084 | 0.2237 | 0.4167 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.5369 | 0.5369 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.2185 | 0.3089 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133 | 0.5369 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0243 | 0.0344 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0133 | 0.5369 | 0.7589 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Transactivation of PXR by luciferase reporter gene assay | ChEMBL. | 16876993 | |
Activity (functional) | Transactivation of FXR by luciferase reporter gene assay | ChEMBL. | 16876993 | |
Activity (functional) | 0 | Transactivation of PXR by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | 0 | Transactivation of FXR by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | = 11 % | Decrease in plasma triglyceride level in C57BL/6J mouse after 5 days at 100 mg/kg/day relative to control | ChEMBL. | 16876993 |
Activity (functional) | = 11 % | Decrease in plasma triglyceride level in C57BL/6J mouse after 5 days at 100 mg/kg/day relative to control | ChEMBL. | 16876993 |
Activity (functional) | = 12 % | Increase in plasma HDL-C level in C57BL/6J mouse after 5 days at 100 mg/kg/day relative to control | ChEMBL. | 16876993 |
Activity (functional) | = 12 % | Increase in plasma HDL-C level in C57BL/6J mouse after 5 days at 100 mg/kg/day relative to control | ChEMBL. | 16876993 |
Activity (functional) | = 81 % | Transactivation of LXRalpha relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | = 81 % | Transactivation of LXRalpha relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | = 105 % | Transactivation of LXRbeta relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | = 105 % | Transactivation of LXRbeta relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | = 520 % | Increase in liver triglyceride level in C57BL/6J mouse after 5 days at 100 mg/kg/day relative to control | ChEMBL. | 16876993 |
Activity (functional) | = 520 % | Increase in liver triglyceride level in C57BL/6J mouse after 5 days at 100 mg/kg/day relative to control | ChEMBL. | 16876993 |
Cp (ADMET) | = 2300 ng/ml | Plasma concentration in C57BL/6J mouse after 5 days at 100 mg/kg/day | ChEMBL. | 16876993 |
Cp (ADMET) | = 2300 ng/ml | Plasma concentration in C57BL/6J mouse after 5 days at 100 mg/kg/day | ChEMBL. | 16876993 |
Drug uptake (ADMET) | = 6300 ng/g | Liver concentration in C57BL/6J mouse after 5 days at 100 mg/kg/day | ChEMBL. | 16876993 |
Drug uptake (ADMET) | = 6300 ng/g | Liver concentration in C57BL/6J mouse after 5 days at 100 mg/kg/day | ChEMBL. | 16876993 |
EC50 (functional) | = 0.03 uM | Transactivation of LXRbeta by luciferase reporter gene assay | ChEMBL. | 16876993 |
EC50 (functional) | = 0.03 uM | Transactivation of LXRbeta by luciferase reporter gene assay | ChEMBL. | 16876993 |
EC50 (functional) | = 0.1 uM | Transactivation of LXRalpha by luciferase reporter gene assay | ChEMBL. | 16876993 |
EC50 (functional) | = 0.1 uM | Transactivation of LXRalpha by luciferase reporter gene assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.008 uM | Binding affinity to LXRbeta by radioligand displacement assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.008 uM | Binding affinity to LXRbeta by radioligand displacement assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.05 uM | Binding affinity to LXRalpha by radioligand displacement assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.05 uM | Binding affinity to LXRalpha by radioligand displacement assay | ChEMBL. | 16876993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.