Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.106 | 0.5989 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0637 | 0.1583 | 0.321 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1123 | 0.665 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.106 | 0.5989 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.106 | 0.5989 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.106 | 0.5989 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1444 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.1123 | 0.665 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1123 | 0.665 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1123 | 0.665 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.106 | 0.5989 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1444 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.106 | 0.5989 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.106 | 0.5989 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.106 | 0.5989 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.106 | 0.5989 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0958 | 0.4933 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Antiviral activity against HSV | ChEMBL. | 16814545 |
Activity (functional) | 0 | Antiviral activity against EBV | ChEMBL. | 16814545 |
Activity (functional) | 0 | Antiviral activity against HIV | ChEMBL. | 16814545 |
Activity (functional) | 0 | Antiviral activity against HHV6 | ChEMBL. | 16814545 |
Activity (functional) | 0 | Antiviral activity against rat CMV | ChEMBL. | 16814545 |
Activity (functional) | 0 | Antiviral activity against guinea pig CMV | ChEMBL. | 16814545 |
Activity (functional) | 0 | Antiviral activity against mouse CMV | ChEMBL. | 16814545 |
IC50 (functional) | > 30 uM | Antiviral activity against human CMV by luciferase reporter gene assay in HFF cells | ChEMBL. | 16814545 |
IC50 (functional) | > 30 uM | Antiviral activity against human CMV by luciferase reporter gene assay in HFF cells | ChEMBL. | 16814545 |
Selectivity ratio (functional) | >= 10 | Ratio of antiviral activity against human CMV to rhesus CMV | ChEMBL. | 16814545 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.